Beyond acne: Current aspects of sebaceous gland biology and function

Christos C. Zouboulis, Mauro Picardo, Qiang Ju, Ichiro Kurokawa, Dániel Törőcsik, T. Bíró, Marlon R. Schneider

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

The sebaceous gland is most commonly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland’s central role in acne pathogenesis, early research had focused on its lipogenic activity. Less studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin, and skin aging have only recently attracted the attention of researchers from different disciplines. Here, we summarize recent multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.

Original languageEnglish
Pages (from-to)319-334
Number of pages16
JournalReviews in Endocrine and Metabolic Disorders
Volume17
Issue number3
DOIs
Publication statusPublished - Sep 1 2016

Fingerprint

Sebaceous Glands
Acne Vulgaris
Research
Sebum
Skin Aging
Lipids
Hair Follicle
Complex Mixtures
Skin Diseases
Innate Immunity
Cell Biology
Transcription Factors
Stem Cells
Research Personnel
Skin

Keywords

  • Cell function
  • Cells
  • Culture models
  • Ex vivo
  • Human
  • In vitro
  • Lipidomics
  • Lipids
  • Neuropeptides
  • Progenitor cells
  • Proteome
  • Sebaceous differentiation
  • Sebaceous gland
  • Sebaceous lineage
  • Sebocyte
  • Sebum
  • Secretome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Zouboulis, C. C., Picardo, M., Ju, Q., Kurokawa, I., Törőcsik, D., Bíró, T., & Schneider, M. R. (2016). Beyond acne: Current aspects of sebaceous gland biology and function. Reviews in Endocrine and Metabolic Disorders, 17(3), 319-334. https://doi.org/10.1007/s11154-016-9389-5

Beyond acne : Current aspects of sebaceous gland biology and function. / Zouboulis, Christos C.; Picardo, Mauro; Ju, Qiang; Kurokawa, Ichiro; Törőcsik, Dániel; Bíró, T.; Schneider, Marlon R.

In: Reviews in Endocrine and Metabolic Disorders, Vol. 17, No. 3, 01.09.2016, p. 319-334.

Research output: Contribution to journalReview article

Zouboulis, CC, Picardo, M, Ju, Q, Kurokawa, I, Törőcsik, D, Bíró, T & Schneider, MR 2016, 'Beyond acne: Current aspects of sebaceous gland biology and function', Reviews in Endocrine and Metabolic Disorders, vol. 17, no. 3, pp. 319-334. https://doi.org/10.1007/s11154-016-9389-5
Zouboulis, Christos C. ; Picardo, Mauro ; Ju, Qiang ; Kurokawa, Ichiro ; Törőcsik, Dániel ; Bíró, T. ; Schneider, Marlon R. / Beyond acne : Current aspects of sebaceous gland biology and function. In: Reviews in Endocrine and Metabolic Disorders. 2016 ; Vol. 17, No. 3. pp. 319-334.
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