Betamethasone augments the antifungal effect of menadione-towards a novel anti-Candida albicans combination therapy

Ágnes Jakab, Tamás Emri, Lilla Sipos, Ágnes Kiss, Renátó Kovács, Viktor Dombrádi, Ádám Kemény-Beke, József Balla, László Majoros, István Pócsi

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5 Citations (Scopus)

Abstract

The fluorinated glucocorticoid betamethasone stimulated both the extracellular phospholipase production and hypha formation of the opportunistic human pathogen Candida albicans and also decreased the efficiency of the polyene antimycotics amphotericin B and nystatin against C. albicans in a dose-dependent manner. Importantly, betamethasone increased synergistically the anti-Candida activity of the oxidative stress generating agent menadione, which may be exploited in future combination therapies to prevent or cure C. albicans infections, in the field of dermatology.

Original languageEnglish
Pages (from-to)973-981
Number of pages9
JournalJournal of basic microbiology
Volume55
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

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Keywords

  • Antimycotics
  • Candida albicans
  • Glucocorticoids
  • Menadione
  • Oxidative stress

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology

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