Beta‐adrenergic receptors of lymphocytes in children with allergic respiratory diseases

István Bittera, Kálmán Gyurkovits, György Falkay, Erna Eck, Mátyás Koltai

Research output: Contribution to journalArticle

Abstract

The beta‐adrenergic receptor binding sites on peripheral lymphocytes in children with bronchial asthma (n = 16) and seasonal allergic rhinitis (n = 8) were examined in comparison with normal controls (n = 18) by means of 124l‐cyanopindolol. The number of beta‐adrenergic receptors was significantly lower in the asthmatic group (858 ± 460/lymphocyte) than in the controls (1564 ± 983/lymphocyte). The value (1891 ± 1502/lymphocyte in children with allergic rhinitis was slightly higher than that in healthy controls. Of the 24 patients suffering from allergic diseases of the lower or upper airways, the bronchial histamine provocation test was performed in 21; 16 gave positive results, while 5 were negative. No difference in beta‐adrenergic receptor count was found between the histamine‐positive and negative patients. Neither was there any correlation between the number of beta‐adrenergic receptors and the high (16/24) and low (8/24) serum IgE concentrations found in allergic patients. The significant decrease in beta‐adrenergic receptor count in asthmatic children lends support to Szentiványi's concept. Further qualitative and quantitative analysis of lymphocyte beta‐adrenergic receptors may provide an individual approach to the treatment of bronchial asthma with beta‐sympathomimetic drugs.

Original languageEnglish
Pages (from-to)69-73
Number of pages5
JournalPediatric pulmonology
Volume5
Issue number2
DOIs
Publication statusPublished - 1988

Keywords

  • Asthma
  • l‐cyanopindolol radioligand assay
  • rhinitis
  • seasonal allergic
  • serum IgE

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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