Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease

Tamás Sperka, János Pitlik, P. Bagossi, J. Tőzsér

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Compounds of a combinatorial monocyclic beta-lactam library were found to be apparently uncompetitive inhibitors of HIV-1 protease, providing lead compounds for a new class of HIV protease inhibitors.

Original languageEnglish
Pages (from-to)3086-3090
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number12
DOIs
Publication statusPublished - Jun 15 2005

Fingerprint

Monobactams
HIV Protease Inhibitors
Lead compounds
beta-Lactams
Human immunodeficiency virus 1 p16 protease

Keywords

  • Beta-lactam library
  • Enzyme kinetics
  • HIV protease
  • Inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease. / Sperka, Tamás; Pitlik, János; Bagossi, P.; Tőzsér, J.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 12, 15.06.2005, p. 3086-3090.

Research output: Contribution to journalArticle

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