Beta-lactam antibiotics functionalized with gem-bisphosphonates

M. Hornyák, J. F. Hartmann, F. J. Sztaricskai, Á Koncz, F. Hernádi

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Abstract

Acylation of amoxycillin and cephalexin with acids III, V and VII, and with isocyanate VIII furnished the corresponding beta-lactam antibiotics (X and XIII-XV, respectively). The antibacterial activity of these new antibiotic analogues against Helicobacter pylori was found to be identical with those of amoxycillin, Augmentin, erythromycin and ciprofloxacin.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalActa pharmaceutica Hungarica
Volume69
Issue number4
Publication statusPublished - Sep 1 1999

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ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Hornyák, M., Hartmann, J. F., Sztaricskai, F. J., Koncz, Á., & Hernádi, F. (1999). Beta-lactam antibiotics functionalized with gem-bisphosphonates. Acta pharmaceutica Hungarica, 69(4), 213-217.