Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation

A. Falus, K. Meretey, D. Bagdy, M. Diószegi, U. Böhm, E. Csák, S. Bozsóky

Research output: Contribution to journalArticle

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Abstract

The anti-platelet activity of beta-2-microglobulin (β2m) specific autoantibodies isolated from sera of patients with autoimmune diseases was tested in direct and ADP-induced aggregation assays. It was established that human anti-β2m autoantibodies and heterologous rabbit anti-β2m antibodies evoke a dose-dependent aggregation of human platelets. Anti-β2m autoantibodies also impaired ADP-induced platelet aggregation. Antibodies with anti-β2m activity could be desorbed from the platelets and lymphocytes of a patient with systemic lupus erythematosus who was not thrombocytopenic. The possibility that such autoantibodies may alter platelet function is considered.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalClinical and Experimental Immunology
Volume47
Issue number1
Publication statusPublished - 1982

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beta 2-Microglobulin
Platelet Aggregation
Autoantibodies
Adenosine Diphosphate
Blood Platelets
Systemic Lupus Erythematosus
Autoimmune Diseases
Anti-Idiotypic Antibodies
Lymphocytes
Rabbits
Antibodies
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Falus, A., Meretey, K., Bagdy, D., Diószegi, M., Böhm, U., Csák, E., & Bozsóky, S. (1982). Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation. Clinical and Experimental Immunology, 47(1), 103-109.

Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation. / Falus, A.; Meretey, K.; Bagdy, D.; Diószegi, M.; Böhm, U.; Csák, E.; Bozsóky, S.

In: Clinical and Experimental Immunology, Vol. 47, No. 1, 1982, p. 103-109.

Research output: Contribution to journalArticle

Falus, A, Meretey, K, Bagdy, D, Diószegi, M, Böhm, U, Csák, E & Bozsóky, S 1982, 'Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation', Clinical and Experimental Immunology, vol. 47, no. 1, pp. 103-109.
Falus, A. ; Meretey, K. ; Bagdy, D. ; Diószegi, M. ; Böhm, U. ; Csák, E. ; Bozsóky, S. / Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation. In: Clinical and Experimental Immunology. 1982 ; Vol. 47, No. 1. pp. 103-109.
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