Benzoylcellulose derivatives as chiral stationary phases for open tubular column chromatography

E. Francotte, K. Grolimund, Z. Juvancz

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The application of cellulose-based stationary phases for chiral separations has been extended to open tubular column chromatography. Efficient columns were obtained by coating the capillaries with mixtures of chiral cellulose materials and conventional achiral stationary phases for gas chromatography. In this study, various siloxane and polyethylene glycol polymers were used as achiral components and mixed with different substituted benzoylcellulose derivatives as chiral components. Systematic investigations were carried out to determine the optimal ratio for the components of the stationary phase. Depending on the chromatographic mode-gas chromatography (GC) or supercritical fluid chromatography (SFC)-the stationary phases were found to behave differently. The applicability of the technique was demonstrated by the resolution of various racemic compounds.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalChirality
Volume5
Issue number4
Publication statusPublished - 1993

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Column chromatography
Cellulose
Gas chromatography
Gas Chromatography
Chromatography
Siloxanes
Supercritical Fluid Chromatography
Derivatives
Polyethylene glycols
Polymers
Coatings

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Benzoylcellulose derivatives as chiral stationary phases for open tubular column chromatography. / Francotte, E.; Grolimund, K.; Juvancz, Z.

In: Chirality, Vol. 5, No. 4, 1993, p. 232-237.

Research output: Contribution to journalArticle

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