Benzodiazepine anticonvulsants accelerate and β-carboline convulsants decelerate the kinetics of [35S]TBPS binding at the chloride ionophore

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Abstract

The effect of flunitrazepam and DMCM was examined on the kinetics of [35S]t-butylbicyclophosphorothionate (TBPS) binding. The enhancing effect of flunitrazepam and the decreasing effect of DMCM on TBPS binding was due o non-equilibrium conditions. The anticonvulsant benzodiazepine increased both the association and dissociation rate constants. The convulsant β-carboline had the opposite effect. Benzodiazepine receptor ligands might affect the convulsant TBPS sites parallel with opening/closing of the chloride ionophores.

Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalEuropean Journal of Pharmacology
Volume117
Issue number2
DOIs
Publication statusPublished - Nov 5 1985

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Keywords

  • Benzodiazepine anticonvulsant
  • Chloride ionophore
  • Convulsant binding site
  • Kinetics of TBPS binding
  • β-Carboline convulsant

ASJC Scopus subject areas

  • Pharmacology

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