Benzo[a]pyrene antibody inhibition of benzo[a]pyrene-induced mutagenesis

Anna Tompa, Gary Curtis, Wayne Ryan, Charles Kuszynski, Robert Langenbach

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An antibody to benzo[a]pyrene (BP) was prepared. The isolated antibody showed a specificity for BP and a low reactivity with another carcinogenic hydrocarbon, 7,12-dimethylbenz[a] anthracene (DMBA). The BP-antibody inhibited the in vitro cytotoxic and mutagenic activity of BP in both a rat embryo fibroblast- and a rat lung cell-mediated mutagenesis system. A possible correlation of these in vitro findings to the in vivo carcinogenesis situation is discussed.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalCancer Letters
Volume7
Issue number2-3
DOIs
Publication statusPublished - Jul 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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