Benzo[a]pyrene antibody inhibition of benzo[a]pyrene-induced mutagenesis

A. Tompa, Gary Curtis, Wayne Ryan, Charles Kuszynski, Robert Langenbach

Research output: Contribution to journalArticle

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Abstract

An antibody to benzo[a]pyrene (BP) was prepared. The isolated antibody showed a specificity for BP and a low reactivity with another carcinogenic hydrocarbon, 7,12-dimethylbenz[a] anthracene (DMBA). The BP-antibody inhibited the in vitro cytotoxic and mutagenic activity of BP in both a rat embryo fibroblast- and a rat lung cell-mediated mutagenesis system. A possible correlation of these in vitro findings to the in vivo carcinogenesis situation is discussed.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalCancer Letters
Volume7
Issue number2-3
DOIs
Publication statusPublished - 1979

Fingerprint

Benzo(a)pyrene
Mutagenesis
Antibodies
9,10-Dimethyl-1,2-benzanthracene
Hydrocarbons
Carcinogenesis
Embryonic Structures
Fibroblasts
Lung
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Biology

Cite this

Benzo[a]pyrene antibody inhibition of benzo[a]pyrene-induced mutagenesis. / Tompa, A.; Curtis, Gary; Ryan, Wayne; Kuszynski, Charles; Langenbach, Robert.

In: Cancer Letters, Vol. 7, No. 2-3, 1979, p. 163-169.

Research output: Contribution to journalArticle

Tompa, A, Curtis, G, Ryan, W, Kuszynski, C & Langenbach, R 1979, 'Benzo[a]pyrene antibody inhibition of benzo[a]pyrene-induced mutagenesis', Cancer Letters, vol. 7, no. 2-3, pp. 163-169. https://doi.org/10.1016/S0304-3835(79)80112-3
Tompa, A. ; Curtis, Gary ; Ryan, Wayne ; Kuszynski, Charles ; Langenbach, Robert. / Benzo[a]pyrene antibody inhibition of benzo[a]pyrene-induced mutagenesis. In: Cancer Letters. 1979 ; Vol. 7, No. 2-3. pp. 163-169.
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