2-(α-Mercaptoalkyl)benzimidazoles (3) reacted with β-halogenoalkylketones (1) or with α,β-unsaturated ketones (2) to form the vinylogue adducts (4) which cyclised to give 2-(3-hydroxytetrahydro- 2-thienyl)benzimidazoles (6). Compounds (4) or (6) reacted with acetic anhydride at room temperature to give the mono- (8) and diacetylated (9) derivatives of (6). At higher temperature dehydroacetylation occurs to give 2-(2,3-dihydro-2-thienyl)benzimidazoles (11).
|Number of pages||6|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - Dec 1 1980|
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