Benefits of resveratrol in women's health

D. Bagchi, D. K. Das, A. Tosaki, M. Bagchi, S. C. Kothari

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Resveratrol and trans-resveratrol are powerful phytoestrogens, present in the skins of grapes and other plant foods and wine, which demonstrate a broad spectrum of pharmacological and therapeutic health benefits. Phytoestrogens are naturally occurring plant-derived nonsteroidal compounds that are functionally and structurally similar to steroidal estrogens, such as estradiol, produced by the body. Various studies, reviewed herein, have demonstrated the health benefits of phytoestrogens in addressing climacteric syndrome including vasomotor symptoms and postmenopausal health risks, as well as their anticarcinogenic, neuroprotective and cardioprotective activities and prostate health and bone formation promoting properties. Conventional HRT drugs have been demonstrated to cause serious adverse effects including stroke and gallbladder disease, as well as endometrial, uterine and breast cancers. Recent research demonstrates that trans-resveratrol binds to human estrogen receptors and increases estrogenic activity in the body. We investigated the effects of protykin, a standardized extract of trans-resveratrol from Polygonum cuspidatum, on cardioprotective function, the incidence of reperfusion-induced arrhythmias and free radical production in isolated ischemic/reperfused rat hearts. The rats were orally treated with two different daily doses of protykin for 3 weeks. Coronary effluents were measured for oxygen free radical production by electron spin resonance (ESR) spectroscopy in treated and drug-free control groups. In rats treated with 50 and 100 mg/kg of protykin, the incidence of reperfusion-induced ventricular fibrillation was reduced from its control value of 83% to 75% (p

Original languageEnglish
Pages (from-to)233-248
Number of pages16
JournalDrugs under Experimental and Clinical Research
Volume27
Issue number5-6
Publication statusPublished - 2001

Fingerprint

Women's Health
Phytoestrogens
Insurance Benefits
Reperfusion
Free Radicals
Fallopia japonica
Gallbladder Diseases
Edible Plants
Uterine Neoplasms
Drug and Narcotic Control
Incidence
Health
Electron Spin Resonance Spectroscopy
Vitis
Phytochemicals
Ventricular Fibrillation
Wine
Endometrial Neoplasms
Osteogenesis
Estrogen Receptors

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology
  • Drug Discovery

Cite this

Bagchi, D., Das, D. K., Tosaki, A., Bagchi, M., & Kothari, S. C. (2001). Benefits of resveratrol in women's health. Drugs under Experimental and Clinical Research, 27(5-6), 233-248.

Benefits of resveratrol in women's health. / Bagchi, D.; Das, D. K.; Tosaki, A.; Bagchi, M.; Kothari, S. C.

In: Drugs under Experimental and Clinical Research, Vol. 27, No. 5-6, 2001, p. 233-248.

Research output: Contribution to journalArticle

Bagchi, D, Das, DK, Tosaki, A, Bagchi, M & Kothari, SC 2001, 'Benefits of resveratrol in women's health', Drugs under Experimental and Clinical Research, vol. 27, no. 5-6, pp. 233-248.
Bagchi D, Das DK, Tosaki A, Bagchi M, Kothari SC. Benefits of resveratrol in women's health. Drugs under Experimental and Clinical Research. 2001;27(5-6):233-248.
Bagchi, D. ; Das, D. K. ; Tosaki, A. ; Bagchi, M. ; Kothari, S. C. / Benefits of resveratrol in women's health. In: Drugs under Experimental and Clinical Research. 2001 ; Vol. 27, No. 5-6. pp. 233-248.
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