Beneficial role of estrogen signaling in glucose homeostasis and energy expenditure

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Glucose is the most important fuel of mammalian cells and its uptake is crucial for cellular metabolism, differentiation, survival and proliferation. The insulin signaling pathway regulates the uptake of glucose and whole-body metabolic homeostasis by transducing extracellular signals through the insulin receptor (IR) to downstream intracellular targets. Dysregulation of insulin secretion or alterations of IR signal transduction pathways is associated with self-generating, progressive insulin resistance in thorough interplay with an imbalance of sexual steroid production. Insulin resistance and the associated metabolic and hormonal alterations predispose patients to a variety of life threatening diseases; such as metabolic syndrome, type-2 diabetes, cardiovascular lesions and malignancies at different sites. Estrogens have beneficial effects on energy metabolism and glucose homeostasis by several pathways. In the central nervous system, hypothalamic nuclei are the pivotal regulators of food intake and energy expenditure by means of their estrogen receptors (ERs). In the pancreatic islet cells, ERs advantageously regulate the biosynthesis and secretion of insulin and maintain the equilibrium of glycogen synthesis and glycogenolysis in the liver by the balanced activation of glycogen synthase and glycolytic enzymes. In the peripheral tissues, ERs advantageously modulate the insulin stimulated glucose uptake through regulation of the phosphorylation of IR protein and increase the expression and translocation of intracellular glucose transporters (GLUTs). Considering the regulatory effects of ERs on food intake, insulin secretion, glucose uptake and metabolic processes, estrogen administration seems to be a therapeutic avenue to repair insulin sensitivity in patients with dysmetabolism and diabetes mellitus.

Original languageEnglish
Title of host publicationGlucose Uptake: Regulation, Signaling Pathways and Health Implications
PublisherNova Science Publishers, Inc.
Pages169-192
Number of pages24
ISBN (Print)9781626186705
Publication statusPublished - May 2013

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Energy Metabolism
Estrogens
Homeostasis
Estrogen Receptors
Insulin
Insulin Receptor
Glucose
Insulin Resistance
Islets of Langerhans
Eating
Glycogenolysis
Glycogen Synthase
Facilitative Glucose Transport Proteins
Glycogen
Type 2 Diabetes Mellitus
Signal Transduction
Diabetes Mellitus
Central Nervous System
Steroids
Phosphorylation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Suba, Z. (2013). Beneficial role of estrogen signaling in glucose homeostasis and energy expenditure. In Glucose Uptake: Regulation, Signaling Pathways and Health Implications (pp. 169-192). Nova Science Publishers, Inc..

Beneficial role of estrogen signaling in glucose homeostasis and energy expenditure. / Suba, Z.

Glucose Uptake: Regulation, Signaling Pathways and Health Implications. Nova Science Publishers, Inc., 2013. p. 169-192.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suba, Z 2013, Beneficial role of estrogen signaling in glucose homeostasis and energy expenditure. in Glucose Uptake: Regulation, Signaling Pathways and Health Implications. Nova Science Publishers, Inc., pp. 169-192.
Suba Z. Beneficial role of estrogen signaling in glucose homeostasis and energy expenditure. In Glucose Uptake: Regulation, Signaling Pathways and Health Implications. Nova Science Publishers, Inc. 2013. p. 169-192
Suba, Z. / Beneficial role of estrogen signaling in glucose homeostasis and energy expenditure. Glucose Uptake: Regulation, Signaling Pathways and Health Implications. Nova Science Publishers, Inc., 2013. pp. 169-192
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