Beneficial effects of theophylline infusions in surgical patients with intra-abdominal hypertension

Zsolt Bodnár, Zoltán Szentkereszty, Zoltán Hajdu, Gilbert A. Boissonneault, S. Sipka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Intra-abdominal hypertension (IAH) can cause high mortality. Recently, we found that IAH was associated with increased serum levels of adenosine and interleukin 10. Our present "hypothesis-generated study" was based on the abovementioned results. Materials and methods: In this uncontrolled clinical trial, a total of 78 patients with IAH were enrolled representing a 13-20 mmHg range of intra-abdominal pressure (IAP). Patients requiring surgical abdominal decompression were excluded. Patients were treated with the following protocols: standard supportive therapy (ST, n = 38) or ST plus infusion with the adenosine receptor antagonist theophylline (T, n = 40). Over the 5-day measurement period, IAP was monitored continuously and serum adenosine concentration and other clinical and laboratory measurements were monitored daily. Mortality was followed for the first 30 days following the diagnosis of IAH. Results: Mortality of ST patients was 55%, which is compatible to other studies. Serum adenosine concentration was found to be directly proportional to IAP. Of the 40 patients receiving T treatment, survival was 100%. An increased survival related to theophylline infusion correlated with improving serum concentrations of IL-10, urea, and creatinine, as well as 24-h urine output, fluid balance, mean arterial pressure, and O 2Sat. Conclusions: Adenosine receptor antagonism with T following IAH diagnosis resulted in markedly reduced mortality in patients with moderated IAH (

Original languageEnglish
Pages (from-to)793-800
Number of pages8
JournalLangenbeck's Archives of Surgery
Volume396
Issue number6
DOIs
Publication statusPublished - Aug 2011

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Intra-Abdominal Hypertension
Theophylline
Adenosine
Mortality
Serum
Pressure
Interleukin-10
Lower Body Negative Pressure
Purinergic P1 Receptor Antagonists
Surgical Decompression
Purinergic P1 Receptors
Water-Electrolyte Balance
Survival
Urea
Creatinine
Arterial Pressure
Clinical Trials
Urine
Therapeutics

Keywords

  • Abdominal compartment syndrome (ACS)
  • Adenosine
  • Intra-abdominal hypertension (IAH)
  • Intra-abdominal pressure (IAP)
  • Theophylline

ASJC Scopus subject areas

  • Surgery

Cite this

Beneficial effects of theophylline infusions in surgical patients with intra-abdominal hypertension. / Bodnár, Zsolt; Szentkereszty, Zoltán; Hajdu, Zoltán; Boissonneault, Gilbert A.; Sipka, S.

In: Langenbeck's Archives of Surgery, Vol. 396, No. 6, 08.2011, p. 793-800.

Research output: Contribution to journalArticle

Bodnár, Zsolt ; Szentkereszty, Zoltán ; Hajdu, Zoltán ; Boissonneault, Gilbert A. ; Sipka, S. / Beneficial effects of theophylline infusions in surgical patients with intra-abdominal hypertension. In: Langenbeck's Archives of Surgery. 2011 ; Vol. 396, No. 6. pp. 793-800.
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