Beneficial effects of remote organ ischemic preconditioning on micro-rheological parameters during liver ischemia-reperfusion in the rat

Zsuzsanna Magyar, Anita Mester, Gabor Nadubinszky, Gabor Varga, Souleiman Ghanem, Viktoria Somogyi, Bence Tanczos, Adam Deak, Laszlo Bidiga, Mihai Oltean, Katalin Peto, N. Németh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Remote ischemic preconditioning (RIPC) can be protective against the damage. However, there is no consensus on the optimal amount of tissue, the number and duration of the ischemic cycles, and the timing of the preconditioning. The hemorheological background of the process is also unknown. OBJECTIVE: To investigate the effects of remote organ ischemic preconditioning on micro-rheological parameters during liver ischemia-reperfusion in rats. METHODS: In anesthetized rats 60-minute partial liver ischemia was induced with 120-minute reperfusion (Control, n = 7). In the preconditioned groups a tourniquet was applied on the left thigh for 3 × 10 minutes 1 hour (RIPC-1, n = 7) or 24 hours (RIPC-24, n = 7) prior to the liver ischemia. Blood samples were taken before the operation and during the reperfusion. Acid-base, hematological parameters, erythrocyte aggregation and deformability were tested. RESULTS: Lactate concentration significantly increased by the end of the reperfusion. Erythrocyte deformability was improved in the RIPC-1 group, erythrocyte aggregation increased during the reperfusion, particularly in the RIPC-24 group. CONCLUSIONS: RIPC alleviated several hemorheological changes caused by the liver I/R. However, the optimal timing of the RIPC cannot be defined based on these results.

Original languageEnglish
Pages (from-to)181-190
Number of pages10
JournalClinical Hemorheology and Microcirculation
Volume70
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • hemorheology
  • Ischemia-reperfusion
  • remote ischemic preconditioning

ASJC Scopus subject areas

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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  • Cite this

    Magyar, Z., Mester, A., Nadubinszky, G., Varga, G., Ghanem, S., Somogyi, V., Tanczos, B., Deak, A., Bidiga, L., Oltean, M., Peto, K., & Németh, N. (2018). Beneficial effects of remote organ ischemic preconditioning on micro-rheological parameters during liver ischemia-reperfusion in the rat. Clinical Hemorheology and Microcirculation, 70(2), 181-190. https://doi.org/10.3233/CH-170351