Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery

J. Váradi, I. Lekli, B. Juhász, I. Bácskay, Gergo Szabo, R. Gesztelyi, Levente Szendrei, E. Varga, I. Bak, Roberta Foresti, Roberto Motterlini, A. Tósaki

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

There is increasing evidence corroborating a protective role of carbon monoxide releasing molecules (CORMs) in injured tissues. Carbon monoxide (CO) carriers have been recently developed as a pharmacological tool to simulate the effect of heme oxygenase-1-derived CO. The effects of CORM-3, a water-soluble CO releaser, on the incidence of reperfusion-induced ventricular fibrillation (VF) and tachycardia (VT) were studied in isolated rat hearts. Hearts were treated with different doses of CORM-3 before the induction of 30 min global ischemia followed by 120 min reperfusion. We found that at concentrations of 25 μM and 50 μM of CORM-3 promoted a significant reduction in the incidence of VF and VT. Thus, the incidence of VF was reduced by 67% (p <0.05) and 92% (p <0.05) with 25 μM and 50 μM of CORM-3, respectively. The protective effect of CORM-3 on the incidence of VT followed the same pattern. The antiarrhythmic protection was associated with a marked attenuation in infarct size, significant decreases in cellular Na+ and Ca2+ gains and K+ loss. Consequently, the recovery of post-ischemic function was significantly improved. In conclusion, CORM-3 exerts beneficial effects against ischemia/reperfusion-induced injury through its abilities to release CO which mediates a cardioprotective action by regulating tissue Na+, K+, and Ca2+ levels.

Original languageEnglish
Pages (from-to)1619-1626
Number of pages8
JournalLife Sciences
Volume80
Issue number17
DOIs
Publication statusPublished - Apr 3 2007

Fingerprint

Carbon Monoxide
Recovery
Molecules
Ventricular Fibrillation
Incidence
Ventricular Tachycardia
Reperfusion
Tissue
Heme Oxygenase-1
Reperfusion Injury
Tachycardia
Rats
Ischemia
Pharmacology
Water

Keywords

  • Carbon monoxide
  • Cardiac function
  • Heart
  • Ischemia
  • Reperfusion

ASJC Scopus subject areas

  • Pharmacology

Cite this

Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery. / Váradi, J.; Lekli, I.; Juhász, B.; Bácskay, I.; Szabo, Gergo; Gesztelyi, R.; Szendrei, Levente; Varga, E.; Bak, I.; Foresti, Roberta; Motterlini, Roberto; Tósaki, A.

In: Life Sciences, Vol. 80, No. 17, 03.04.2007, p. 1619-1626.

Research output: Contribution to journalArticle

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