Beneficial effect of chronic treatment with Org 2766 and α-MSH on impaired reversal learning of rats with bilateral lesions of the parafascicular area

C. Nyakas, H. Dick Veldhuis, David De Wied

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The effects of chronic treatment with the ACTH-(4-9) analogue Org 2766, α-MSH and γ2-MSH were studied on T-maze reversal learning and on behavior assessed on the basis of open-field and other gross behavioral activities, grasping responses, inspection of various reflexes and electrical footshock sensitivity of rats with parafascicular lesions or sham-lesions. Repeated administration of Org 2766 and α-MSH to parafascicular area-lesioned rats resulted in functional recovery of impaired T-maze reversal learning. The structurally related neuropeptide γ2-MSH was without any effect. The α-MSH effect did not depend on time after lesioning as treatments during the first or second post-operative week were equally effective. Chronic peptide treatments did not change disturbed motor functions of parafascicular-lesioned rats, as measured by open-field activity, other gross behavioral activities and grasping responses. Since acute peptide treatments did not affect the impaired reversal learning performance of lesioned rats, the beneficial effect of Org 2766 and α-MSH could not be explained as a short-term effect on attention and motivation. It was more likely to be an accelerated recovery of cognitive function as a result of long-term neurotropic influences.

Original languageEnglish
Pages (from-to)257-265
Number of pages9
JournalBrain Research Bulletin
Volume15
Issue number3
DOIs
Publication statusPublished - 1985

Fingerprint

Reversal Learning
Melanocyte-Stimulating Hormones
Maze Learning
Therapeutics
Peptides
Recovery of Function
Neuropeptides
Cognition
Reflex
Org 2766
Motivation

Keywords

  • Grasping response
  • Gross behavior
  • Open-field behavior
  • Org 2766
  • Parafascicular area lesion
  • Reversal learning
  • α-MSH γ-MSH

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Beneficial effect of chronic treatment with Org 2766 and α-MSH on impaired reversal learning of rats with bilateral lesions of the parafascicular area. / Nyakas, C.; Veldhuis, H. Dick; De Wied, David.

In: Brain Research Bulletin, Vol. 15, No. 3, 1985, p. 257-265.

Research output: Contribution to journalArticle

@article{2cabe37cd9be49b3859c7865f495c6b3,
title = "Beneficial effect of chronic treatment with Org 2766 and α-MSH on impaired reversal learning of rats with bilateral lesions of the parafascicular area",
abstract = "The effects of chronic treatment with the ACTH-(4-9) analogue Org 2766, α-MSH and γ2-MSH were studied on T-maze reversal learning and on behavior assessed on the basis of open-field and other gross behavioral activities, grasping responses, inspection of various reflexes and electrical footshock sensitivity of rats with parafascicular lesions or sham-lesions. Repeated administration of Org 2766 and α-MSH to parafascicular area-lesioned rats resulted in functional recovery of impaired T-maze reversal learning. The structurally related neuropeptide γ2-MSH was without any effect. The α-MSH effect did not depend on time after lesioning as treatments during the first or second post-operative week were equally effective. Chronic peptide treatments did not change disturbed motor functions of parafascicular-lesioned rats, as measured by open-field activity, other gross behavioral activities and grasping responses. Since acute peptide treatments did not affect the impaired reversal learning performance of lesioned rats, the beneficial effect of Org 2766 and α-MSH could not be explained as a short-term effect on attention and motivation. It was more likely to be an accelerated recovery of cognitive function as a result of long-term neurotropic influences.",
keywords = "Grasping response, Gross behavior, Open-field behavior, Org 2766, Parafascicular area lesion, Reversal learning, α-MSH γ-MSH",
author = "C. Nyakas and Veldhuis, {H. Dick} and {De Wied}, David",
year = "1985",
doi = "10.1016/0361-9230(85)90148-0",
language = "English",
volume = "15",
pages = "257--265",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Beneficial effect of chronic treatment with Org 2766 and α-MSH on impaired reversal learning of rats with bilateral lesions of the parafascicular area

AU - Nyakas, C.

AU - Veldhuis, H. Dick

AU - De Wied, David

PY - 1985

Y1 - 1985

N2 - The effects of chronic treatment with the ACTH-(4-9) analogue Org 2766, α-MSH and γ2-MSH were studied on T-maze reversal learning and on behavior assessed on the basis of open-field and other gross behavioral activities, grasping responses, inspection of various reflexes and electrical footshock sensitivity of rats with parafascicular lesions or sham-lesions. Repeated administration of Org 2766 and α-MSH to parafascicular area-lesioned rats resulted in functional recovery of impaired T-maze reversal learning. The structurally related neuropeptide γ2-MSH was without any effect. The α-MSH effect did not depend on time after lesioning as treatments during the first or second post-operative week were equally effective. Chronic peptide treatments did not change disturbed motor functions of parafascicular-lesioned rats, as measured by open-field activity, other gross behavioral activities and grasping responses. Since acute peptide treatments did not affect the impaired reversal learning performance of lesioned rats, the beneficial effect of Org 2766 and α-MSH could not be explained as a short-term effect on attention and motivation. It was more likely to be an accelerated recovery of cognitive function as a result of long-term neurotropic influences.

AB - The effects of chronic treatment with the ACTH-(4-9) analogue Org 2766, α-MSH and γ2-MSH were studied on T-maze reversal learning and on behavior assessed on the basis of open-field and other gross behavioral activities, grasping responses, inspection of various reflexes and electrical footshock sensitivity of rats with parafascicular lesions or sham-lesions. Repeated administration of Org 2766 and α-MSH to parafascicular area-lesioned rats resulted in functional recovery of impaired T-maze reversal learning. The structurally related neuropeptide γ2-MSH was without any effect. The α-MSH effect did not depend on time after lesioning as treatments during the first or second post-operative week were equally effective. Chronic peptide treatments did not change disturbed motor functions of parafascicular-lesioned rats, as measured by open-field activity, other gross behavioral activities and grasping responses. Since acute peptide treatments did not affect the impaired reversal learning performance of lesioned rats, the beneficial effect of Org 2766 and α-MSH could not be explained as a short-term effect on attention and motivation. It was more likely to be an accelerated recovery of cognitive function as a result of long-term neurotropic influences.

KW - Grasping response

KW - Gross behavior

KW - Open-field behavior

KW - Org 2766

KW - Parafascicular area lesion

KW - Reversal learning

KW - α-MSH γ-MSH

UR - http://www.scopus.com/inward/record.url?scp=0022392647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022392647&partnerID=8YFLogxK

U2 - 10.1016/0361-9230(85)90148-0

DO - 10.1016/0361-9230(85)90148-0

M3 - Article

VL - 15

SP - 257

EP - 265

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 3

ER -