Clinico-pathological description of five cases of subacute spongiform encephalopathy. The E.E.G. performed in four cases showed the characteristic pattern of the disease. Alterations of astrocytes in the cerebral cortex preceding the spongy lesions and nerve cell alterations were found in each of the cases in variable intensity and topography. In one case the lesions were accentuated in the basal ganglia. As the clinicopathological features of this observation were the same as in the other cases it was included to the group of spongiform encephalopathies. Astrocytosis is considered as the first morphological sign, cortical spongiform alterations and nerve cell destruction, however, are suggested as its sequelae. Vascular factors probably determine the topography of the lesions, but are of no essential pathogenic importance.
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Clinical Neurology
- Cellular and Molecular Neuroscience