Behavioural studies with a newly developed neuroprotective KYNA-amide

Levente Gellért, Dániel Varga, Marian Ruszka, József Toldi, Tamás Farkas, István Szatmári, Ferenc Fülöp, László Vécsei, Zsolt Kis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The neuroactive properties and neuroprotective potential of endogenous l-kynurenine, kynurenic acid (KYNA) and its derivatives are well established. KYNA acts as an antagonist on the obligatory co-agonist glycine site, and has long been at the focus of neuroprotective trials. Unfortunately, KYNA is barely able to cross the blood-brain barrier. Accordingly, the development and synthesis of KYNA analogs which can readily cross the BBB have been at the focus of research interest with the aim of neuroprotection. Earlier we reported a new KYNA-amide crosses the BBB and proved neuroprotective in several experiments. In the present study, we investigated the locomotor activity, working memory performance, and also the long-lasting, consolidated reference memory of animals treated intraperitoneally (i.p.) with the novel analog. The effects of the novel analog on the spatial orientation and learning ability of rats were assessed in the Morris water maze (MWM) paradigm. The effects on locomotor activity of mice was assessed in the open field (OF) paradigm, and those on the spatial orientation and learning ability of mice were investigated in the radial arm maze (RAM) paradigm. It emerged that there is a dose of this KYNA-amide which is neuroprotective, but does not worsen the cognitive function of the brain. This result is significant in that a putative neuroprotectant without adverse cognitive side-effects is of great benefit.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalJournal of neural transmission
Volume119
Issue number2
DOIs
Publication statusPublished - Feb 1 2012

Keywords

  • Behavioral studies
  • Mice
  • Open-field
  • Radial maze
  • Rat
  • Water maze

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Behavioural studies with a newly developed neuroprotective KYNA-amide'. Together they form a unique fingerprint.

  • Cite this