Behavioural, electrophysiological and histopathological changes following sustained stimulation of the perforant pathway input to the hippocampus: Effect of the NMDA receptor antagonist, CGP 39551

Aarne Ylinen, Hannele Lahtinen, Jouni Sirviö, Juhani Partanen, Ari Asikainen, Attila Gulyas, T. Freund, Paavo Riekkinen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Sustained stimulation of the perforant path has been shown to damage the CA1 area and impair spatial memory in rats. The pattern of cell death is similar in human epileptics, who also exhibit memory deficits. In this study we demonstrate that the learning/memory impairment in water maze test and the development of interictal spikes that also followed stimulation-induced damage were antagonized by CGP 39551. Pretreatment with this NMDA receptor antagonist also slightly diminished somatostatin cell loss in the hilus but not CA1 pyramidal cell damage. These results indicate that the impairment of spatial learning/memory seems to be dependent not only on the degree of cell degeneration in the CA1 subfield of the hippocampus but also on the frequency of interictal spikes, at least in this model of epilepsy.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalBrain Research
Volume553
Issue number2
DOIs
Publication statusPublished - Jul 12 1991

Fingerprint

CGP 39551
Perforant Pathway
N-Methyl-D-Aspartate Receptors
Hippocampus
Somatostatin-Secreting Cells
Pyramidal Cells
Memory Disorders
Epilepsy
Cell Death
Learning
Water
Spatial Memory

Keywords

  • CGP 39551
  • Epilepsy
  • Hippocampus
  • N-Methyl-d-aspartate receptor antagonist
  • Perforant pathway stimulation
  • Spatial memory

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Behavioural, electrophysiological and histopathological changes following sustained stimulation of the perforant pathway input to the hippocampus : Effect of the NMDA receptor antagonist, CGP 39551. / Ylinen, Aarne; Lahtinen, Hannele; Sirviö, Jouni; Partanen, Juhani; Asikainen, Ari; Gulyas, Attila; Freund, T.; Riekkinen, Paavo.

In: Brain Research, Vol. 553, No. 2, 12.07.1991, p. 195-200.

Research output: Contribution to journalArticle

Ylinen, Aarne ; Lahtinen, Hannele ; Sirviö, Jouni ; Partanen, Juhani ; Asikainen, Ari ; Gulyas, Attila ; Freund, T. ; Riekkinen, Paavo. / Behavioural, electrophysiological and histopathological changes following sustained stimulation of the perforant pathway input to the hippocampus : Effect of the NMDA receptor antagonist, CGP 39551. In: Brain Research. 1991 ; Vol. 553, No. 2. pp. 195-200.
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