Viselkedési mintázatok vizsgálata a bazális ganglionok és a limbikus rendszer átfedésében

Translated title of the contribution: Behavioural aspects of a modified crosstalk between basal ganglia and limbic system in Parkinson’s disease

Orsolya Györfi, Helga Nagy, Magdolna Bokor, S. Kéri

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Dysfunctions in dopaminergic neurotransmission lead to motor symptoms and cognitive impairments associated with behavioural disturbances. Parkinson’s disease is a neurodegenerative disorder which is primarily characterized by an abnormal basal ganglia activity. Recently, increased attention has been directed towards the hippocampus in the development of non-motor symptoms. Given the temporal progression of the disease, dopaminergic depletion firstly affects the dorsal striatum leaving the ventral striatum relatively intact. However, it is possible that the structure and function of the hippocampus shows alterations even in early stages of Parkinson’s disease. Subtle cognitive impairments occur in the earliest stages, and therefore Parkinson’s disease could provide a unique model to investigate the effect of replacement therapies on a neural network with different baseline dopaminergic levels. Strong evidence suggests that dopaminergic medications improve the motor symptoms, but these medications might have disadvantageous effects on cognitive functions. In this review, we examine the role of dopaminergic changes across several cognitive and behavioural impairments observed in Parkinson’s disease, with a special reference to hippocampal dysfunctions.

Translated title of the contributionBehavioural aspects of a modified crosstalk between basal ganglia and limbic system in Parkinson’s disease
Original languageHungarian
Pages (from-to)87-92
Number of pages6
JournalNeuropsychopharmacologia Hungarica
Volume18
Issue number2
Publication statusPublished - Jun 1 2016

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuropsychology and Physiological Psychology
  • Clinical Neurology

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