Behavioural and functional neurotoxicological changes caused by cadmium in a three-generational study in rats

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

1 Three consecutive generations of Wistar rats were orally treated by gavage with 3.5, 7.0 or 14.0 mg/kg cadmium (in form of cadmium chloride diluted in distilled water) over the period of pregnancy, lactation and 8 weeks after weaning. 2 Behavioural (open field behaviour) and electrophysiological (spontaneous and evoked cortical activity, etc.) parameters of male rats from each generation were investigated at the age of 12 weeks. 3 The main behavioural outcomes were change in vertical exploration activity (rearing) and increased exploration of an open field centre. The spontaneous and evoked electrophysiological variables showed dose- and generation-dependent changes (increased frequencies in the electrocorticogram, lengthened latency and duration of evoked potentials, etc.) signalling a change in neural functions. 4 The data show that low-level, multigeneration exposure to inorganic cadmium can affect functions of the nervous system. This suggests that cadmium exposed human populations may be at risk of developing nervous system disorders.

Original languageEnglish
Pages (from-to)691-699
Number of pages9
JournalHuman and Experimental Toxicology
Volume16
Issue number12
Publication statusPublished - Dec 1997

Fingerprint

Cadmium
Rats
Neurology
Cadmium Chloride
Bioelectric potentials
Weaning
Nervous System Diseases
Evoked Potentials
Lactation
Nervous System
Wistar Rats
Pregnancy
Water
Population

Keywords

  • Cadmium chloride
  • Conduction velocity
  • Cortical evoked potential
  • Electrocorticogram
  • Open field
  • Rat
  • Refractory period

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

@article{846efb7bf0a44e9ca3c4e0332e8bd387,
title = "Behavioural and functional neurotoxicological changes caused by cadmium in a three-generational study in rats",
abstract = "1 Three consecutive generations of Wistar rats were orally treated by gavage with 3.5, 7.0 or 14.0 mg/kg cadmium (in form of cadmium chloride diluted in distilled water) over the period of pregnancy, lactation and 8 weeks after weaning. 2 Behavioural (open field behaviour) and electrophysiological (spontaneous and evoked cortical activity, etc.) parameters of male rats from each generation were investigated at the age of 12 weeks. 3 The main behavioural outcomes were change in vertical exploration activity (rearing) and increased exploration of an open field centre. The spontaneous and evoked electrophysiological variables showed dose- and generation-dependent changes (increased frequencies in the electrocorticogram, lengthened latency and duration of evoked potentials, etc.) signalling a change in neural functions. 4 The data show that low-level, multigeneration exposure to inorganic cadmium can affect functions of the nervous system. This suggests that cadmium exposed human populations may be at risk of developing nervous system disorders.",
keywords = "Cadmium chloride, Conduction velocity, Cortical evoked potential, Electrocorticogram, Open field, Rat, Refractory period",
author = "L. Nagymajt{\'e}nyi and H. Schulz and I. D{\'e}si",
year = "1997",
month = "12",
language = "English",
volume = "16",
pages = "691--699",
journal = "Human and Experimental Toxicology",
issn = "0960-3271",
publisher = "SAGE Publications Inc.",
number = "12",

}

TY - JOUR

T1 - Behavioural and functional neurotoxicological changes caused by cadmium in a three-generational study in rats

AU - Nagymajtényi, L.

AU - Schulz, H.

AU - Dési, I.

PY - 1997/12

Y1 - 1997/12

N2 - 1 Three consecutive generations of Wistar rats were orally treated by gavage with 3.5, 7.0 or 14.0 mg/kg cadmium (in form of cadmium chloride diluted in distilled water) over the period of pregnancy, lactation and 8 weeks after weaning. 2 Behavioural (open field behaviour) and electrophysiological (spontaneous and evoked cortical activity, etc.) parameters of male rats from each generation were investigated at the age of 12 weeks. 3 The main behavioural outcomes were change in vertical exploration activity (rearing) and increased exploration of an open field centre. The spontaneous and evoked electrophysiological variables showed dose- and generation-dependent changes (increased frequencies in the electrocorticogram, lengthened latency and duration of evoked potentials, etc.) signalling a change in neural functions. 4 The data show that low-level, multigeneration exposure to inorganic cadmium can affect functions of the nervous system. This suggests that cadmium exposed human populations may be at risk of developing nervous system disorders.

AB - 1 Three consecutive generations of Wistar rats were orally treated by gavage with 3.5, 7.0 or 14.0 mg/kg cadmium (in form of cadmium chloride diluted in distilled water) over the period of pregnancy, lactation and 8 weeks after weaning. 2 Behavioural (open field behaviour) and electrophysiological (spontaneous and evoked cortical activity, etc.) parameters of male rats from each generation were investigated at the age of 12 weeks. 3 The main behavioural outcomes were change in vertical exploration activity (rearing) and increased exploration of an open field centre. The spontaneous and evoked electrophysiological variables showed dose- and generation-dependent changes (increased frequencies in the electrocorticogram, lengthened latency and duration of evoked potentials, etc.) signalling a change in neural functions. 4 The data show that low-level, multigeneration exposure to inorganic cadmium can affect functions of the nervous system. This suggests that cadmium exposed human populations may be at risk of developing nervous system disorders.

KW - Cadmium chloride

KW - Conduction velocity

KW - Cortical evoked potential

KW - Electrocorticogram

KW - Open field

KW - Rat

KW - Refractory period

UR - http://www.scopus.com/inward/record.url?scp=0031442192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031442192&partnerID=8YFLogxK

M3 - Article

C2 - 9429082

AN - SCOPUS:0031442192

VL - 16

SP - 691

EP - 699

JO - Human and Experimental Toxicology

JF - Human and Experimental Toxicology

SN - 0960-3271

IS - 12

ER -