Behavioral traits are affected by selective breeding for increased wheel-running behavior in mice

I. Jónás, K. A. Schubert, A. C. Reijne, J. Scholte, T. Garland, M. P. Gerkema, A. J W Scheurink, C. Nyakas, G. Van Dijk

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Voluntary physical activity may be related to personality traits. Here, we investigated these relations in two mouse lines selectively bred for high voluntary wheel-running behavior and in one non-selected control line. Selection lines were more explorative and "information gathering" in the open-field test, either with increased upright positions or horizontal locomotion toward the middle ring. Furthermore, one of the selection lines had an increased risk-taking behavior relative to the control line in approaching a novel object placed in the center of the open field. However, anxiety behavior was increased in selection lines during the plus-maze test. Maze learning was not statistically different among lines, but routine behavior was increased in both selection lines when the maze exit after 2 days of testing was displaced. Specifically, in the displaced maze, selected mice traveled more frequently to the old, habituated exit, bypassing the new exit attached to their home cage. Although the generality of the results would need to be confirmed in future studies including all eight lines in the selection experiment, the increased routine and exploratory behavior (at least in the lines used in the present study) may be adaptive to sustain high activity levels.

Original languageEnglish
Pages (from-to)542-550
Number of pages9
JournalBehavior Genetics
Volume40
Issue number4
DOIs
Publication statusPublished - Jul 2010

Fingerprint

selective breeding
selection methods
wheels
Running
mice
Maze Learning
risk behavior
Exploratory Behavior
testing
Locomotion
anxiety
Risk-Taking
physical activity
locomotion
Personality
cages
learning
Anxiety
breeds
Selective Breeding

Keywords

  • Anxiety
  • Experimental evolution
  • Maze learning
  • Open field
  • Routine behavior
  • Trait

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics
  • Medicine(all)

Cite this

Jónás, I., Schubert, K. A., Reijne, A. C., Scholte, J., Garland, T., Gerkema, M. P., ... Van Dijk, G. (2010). Behavioral traits are affected by selective breeding for increased wheel-running behavior in mice. Behavior Genetics, 40(4), 542-550. https://doi.org/10.1007/s10519-010-9359-8

Behavioral traits are affected by selective breeding for increased wheel-running behavior in mice. / Jónás, I.; Schubert, K. A.; Reijne, A. C.; Scholte, J.; Garland, T.; Gerkema, M. P.; Scheurink, A. J W; Nyakas, C.; Van Dijk, G.

In: Behavior Genetics, Vol. 40, No. 4, 07.2010, p. 542-550.

Research output: Contribution to journalArticle

Jónás, I, Schubert, KA, Reijne, AC, Scholte, J, Garland, T, Gerkema, MP, Scheurink, AJW, Nyakas, C & Van Dijk, G 2010, 'Behavioral traits are affected by selective breeding for increased wheel-running behavior in mice', Behavior Genetics, vol. 40, no. 4, pp. 542-550. https://doi.org/10.1007/s10519-010-9359-8
Jónás, I. ; Schubert, K. A. ; Reijne, A. C. ; Scholte, J. ; Garland, T. ; Gerkema, M. P. ; Scheurink, A. J W ; Nyakas, C. ; Van Dijk, G. / Behavioral traits are affected by selective breeding for increased wheel-running behavior in mice. In: Behavior Genetics. 2010 ; Vol. 40, No. 4. pp. 542-550.
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