Behavioral effects of subchronic inorganic manganese exposure in rats

T. Vezér, A. Kurunczi, M. Náray, A. Papp, L. Nagymajtényi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Manganese, an essential micronutrient, is a potential neurotoxicant in prolonged overexposure. Parkinson-like syndrome, motor deficit, disturbed psychomotor development are typical signs of neuropathological alterations due to Mn in humans. Methods: Young adult rats, in three groups of 16 each, received 15 and 59 mg/kg b.w. MnCl2, (control: distilled water) via gavage for 10 weeks, and were kept for further 12 weeks. Correlation of MnCl2 exposure to body and organ weights, neurobehavioral effects (spatial memory, exploratory activity, psychomotor performance, pre-pulse inhibition), and histopathological changes (gliosis) was sought. Results: By the end of treatment, Mn accumulated in blood, cortex, hippocampus, and parenchymal tissues. Body and organ weights were reduced in high dose rats. All treated rats showed hypoactivity, decreased memory performance, and diminished sensorimotor reaction. In the dentate gyrus of these, GFAP immunoreactivity increased. During the post-treatment period, body weight of the high dose group remained decreased, locomotor activity returned to control, but the lasting effect of MnCl2 could be revealed by amphetamine. Conclusion: Using complex methodology, new data were obtained regarding the relationship between the long-term effects of MnCl2 at neuronal and behavioral level.

Original languageEnglish
Pages (from-to)841-852
Number of pages12
JournalAmerican Journal of Industrial Medicine
Volume50
Issue number11
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Manganese
Organ Size
Body Weight
Psychomotor Performance
Gliosis
Micronutrients
Dentate Gyrus
Amphetamine
Locomotion
Young Adult
Hippocampus
manganese chloride
Water
Therapeutics

Keywords

  • d-amphetamine
  • Exploratory activity
  • GFAP
  • Manganese
  • Maze
  • Open field
  • Psychomotor performance
  • Rat
  • Sensorimotor gating
  • Spatial learning

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Behavioral effects of subchronic inorganic manganese exposure in rats. / Vezér, T.; Kurunczi, A.; Náray, M.; Papp, A.; Nagymajtényi, L.

In: American Journal of Industrial Medicine, Vol. 50, No. 11, 11.2007, p. 841-852.

Research output: Contribution to journalArticle

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