Behavioral effects of perinatal opioid exposure

Anna Fodor, Júlia Tímár, D. Zelena

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Opioids are among the world's oldest known drugs used mostly for pain relief, but recreational use is also widespread. A particularly important problem is opioid exposure in females, as their offspring can also be affected. Adverse intrauterine and postnatal environments can affect offspring development and may lead to various disabilities later in life. It is clear that repetitive painful experiences, such as randomly occurring invasive procedures during neonatal intensive care, can permanently alter neuronal and synaptic organization and therefore later behavior. At the same time, analgesic drugs can also be harmful, inducing neuronal apoptosis or withdrawal symptoms in the neonate and behavioral alterations in adulthood. Hence, risk-benefit ratios should be taken into consideration when pain relief is required during pregnancy or in neonates. Recreational use of opioids can also alter many aspects of life. Intrauterine opioid exposure has many toxic effects, inducing poor pregnancy outcomes due to underdevelopment, but it is believed that later negative consequences are more related to environmental factors such as a chaotic lifestyle and inadequate prenatal care. One of the crucial components is maternal care, which changes profoundly in addicted mothers. In substance-dependent mothers, pre- and postnatal care has special importance, and controlled treatment with a synthetic opioid (e.g., methadone) could be beneficial. We aimed to summarize and compare human and rodent data, as it is important to close the gap between scientific knowledge and societal policies. Special emphasis is given to gender differences in the sensitivity of offspring to perinatal opioid exposure.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalLife Sciences
Volume104
Issue number1-2
DOIs
Publication statusPublished - May 28 2014

Fingerprint

Opioid Analgesics
Prenatal Care
Mothers
Newborn Infant
Postnatal Care
Neonatal Intensive Care
Pain
Substance Withdrawal Syndrome
Poisons
Methadone
Pregnancy Outcome
Analgesics
Life Style
Rodentia
Odds Ratio
Apoptosis
Pregnancy
Pharmaceutical Preparations

Keywords

  • Gender difference
  • Methadone
  • Morphine
  • Pain killer
  • Street drug
  • Stress

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Behavioral effects of perinatal opioid exposure. / Fodor, Anna; Tímár, Júlia; Zelena, D.

In: Life Sciences, Vol. 104, No. 1-2, 28.05.2014, p. 1-8.

Research output: Contribution to journalArticle

Fodor, Anna ; Tímár, Júlia ; Zelena, D. / Behavioral effects of perinatal opioid exposure. In: Life Sciences. 2014 ; Vol. 104, No. 1-2. pp. 1-8.
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