Behavioral effects of centrally administered LH-RH agonist in rats

Tibor Kádár, G. Telegdy, Andrew V. Schally

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after intracerebroventricular (ICV) administrations to male rats. The doses applied were 10, 100 and 1000 ng/animal. In the open field the 1000 ng ICV dose of the peptide D-Trp-6-LH-RH suppressed the ambulation, rearing and grooming. In a combined catalepsy test, the 10 ng and 1000 ng dose of D-Trp-6-LH-RH increased the total duration of immobility. The LH-RH agonist inhibited stereotyped behavior induced by both apomorphine and amphetamine, and the effects of 100 and 1000 ng D-Trp-6-LH-RH were significant. Naloxone in a dose of 0.5 mg/kg IP totally abolished the inhibition of apomorphine-induced stereotypy by 1000 ng D-Trp-6-LH-RH, but the opiate antagonist did not influence amphetamine-induced stereotypy but significantly potentiated the inhibitory effect of 100 ng D-Trp-6-LH-RH. In the tail-flick test the latencies were significantly increased after D-Trp-6-LH-RH ICV, both 20 or 40 min after the injections. The peptide-induced analgesia was totally naloxone reversible. The results indicate that the agonist analog of LH-RH exert potent actions on the central nervous system, and the mechanism of effects may involve dopaminergic transmisssion and/or endogenous opiates.

Original languageEnglish
Pages (from-to)601-605
Number of pages5
JournalPhysiology and Behavior
Volume51
Issue number3
DOIs
Publication statusPublished - 1992

Fingerprint

Triptorelin Pamoate
Gonadotropin-Releasing Hormone
Apomorphine
Amphetamine
Naloxone
Opiate Alkaloids
Stereotyped Behavior
Catalepsy
Grooming
Peptides
Opioid Peptides
Analgesia
Walking
Tail
Central Nervous System
Injections

Keywords

  • Analgesia
  • Antisterotypic activity
  • Dopaminergic system
  • LHRH
  • LHRH analog
  • Naloxone-reversible

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Behavioral effects of centrally administered LH-RH agonist in rats. / Kádár, Tibor; Telegdy, G.; Schally, Andrew V.

In: Physiology and Behavior, Vol. 51, No. 3, 1992, p. 601-605.

Research output: Contribution to journalArticle

Kádár, Tibor ; Telegdy, G. ; Schally, Andrew V. / Behavioral effects of centrally administered LH-RH agonist in rats. In: Physiology and Behavior. 1992 ; Vol. 51, No. 3. pp. 601-605.
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