Behavioral and neurotoxicological effects of subchronic manganese exposure in rats

Tünde Vezér, A. Papp, Z. Hoyk, Csaba Varga, Miklós Náray, L. Nagymajtényi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In male Wistar rats, behavioral and electrophysiological investigations, and blood and brain manganese level determinations, were performed; during 10 weeks treatment with low-dose manganese chloride and a 12 weeks post-treatment period. Three groups of 16 animals each received daily doses of 14.84 and 59.36 mg/kg b.w. MnCl2 (control: distilled water) via gavage. During treatment period, Mn accumulation was seen first in the blood, then in the brain samples of the high-dose animals. Short- and long-term spatial memory performance of the treated animals decreased, spontaneous open field activity (OF) was reduced. The number of acoustic startle responses (ASR), and the pre-pulse inhibition (PPI) of these, diminished. In the cortical and hippocampal spontaneous activity, power spectrum was shifted to higher frequencies. The latency of the sensory evoked potentials increased, and their duration, decreased. By the end of the post-treatment period, Mn levels returned to the control in all samples. The impairment of long-term spatial memory remained, as did the number of acoustic startle responses. Pre-pulse inhibition, however, returned to the pre-treatment levels. The changes of the open field activity disappeared but a residual effect could be revealed by administration of d-amphetamine. The electrophysiological effects were partially reversed. By applying a complex set of methods, it was possible to obtain new data for a better-based relationship between the known effects of Mn at neuronal level and the behavioral and electrophysiological outcomes of Mn exposure.

Original languageEnglish
Pages (from-to)797-810
Number of pages14
JournalEnvironmental Toxicology and Pharmacology
Volume19
Issue number3
DOIs
Publication statusPublished - May 2005

Fingerprint

Manganese
Rats
Animals
Startle Reflex
Brain
Blood
Acoustics
Long-Term Memory
Data storage equipment
Dextroamphetamine
Bioelectric potentials
Power spectrum
Therapeutics
Evoked Potentials
Water
Wistar Rats
manganese chloride
Spatial Memory
Inhibition (Psychology)

Keywords

  • Acoustic startle response
  • Cortical activity
  • GFAP
  • Manganese chloride
  • Maze learning
  • Spontaneous locomotor activity

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Pharmacology

Cite this

Behavioral and neurotoxicological effects of subchronic manganese exposure in rats. / Vezér, Tünde; Papp, A.; Hoyk, Z.; Varga, Csaba; Náray, Miklós; Nagymajtényi, L.

In: Environmental Toxicology and Pharmacology, Vol. 19, No. 3, 05.2005, p. 797-810.

Research output: Contribution to journalArticle

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