Bed rest immobilization with various oral sodium supply

Plasma hormones and body fluids

Helmut G. Hinghofer-Szalakay, Z. László, Daniela Jezova, Andreas Rössler, Bernd Haditsch, Karl Pilz, Herfried Passath, Herman Scharfetter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective. To answer the question if plasma hormone concentrations (plasma renin activity PRA, vasopressin - pAVP, and aldosterone concentration) due to antiorthostatic immobilization (8 days -6° head-down tilt bed rest - HDBR) are altered by oral salt load, we provided constant sodium supply during 4 days ambulatory conditions followed by 8 days HDBR in 10 normotensive men. Methods. A,low' (LS: 143±10 mM) and,high' (HS: 434±17 mM Na+-/d excreted) sodium treatment were provided in randomized order, separated ≥1 mo. Before and at the end of HDBR, hemodynamic variables and thoracic impedance were determined, and blood was taken for aldosterone and PRA, venous hematocrit, and plasma mass density. Extracellular fluid volume and pAVP were determined every second day. Whole body electrical impedance spectroscopy was employed to assess changes in extracellular volume, hormone determinations were done with radioimmunoassay, mass density measurements with the mechanical oscillator technique. Results. Extracellular volume decreased with HDBR (LS: -4.0%, p=0.002; HS: -5.8%, p=0.018) without significant difference between salt treatments. Resting hormone levels were not altered by HDBR, but pAVP was lower (5.5±0.1 pg/ml) in HS than in LS (7.2±0.3 pg/ml) as was plasma aldosterone (HS: 69±7 pg/ml, LS: 180±24 pg/ml). On the other hand, HDBR reduced extracellular volume by ?5% irrespective of dietary sodium supply. Conclusions. Our data support the hypothesis that hormonal activities are more affected by oral salt load than by simulated short-term space flight, and suggest that the reduction of extracellular fluid volume due to head down bed rest is not influenced by moderate changes of dietary sodium supply.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalEndocrine Regulations
Volume36
Issue number4
Publication statusPublished - Nov 2002

Fingerprint

Bed Rest
Body Fluids
Immobilization
Aldosterone
Sodium
Hormones
Dietary Sodium
Salts
Extracellular Fluid
Electric Impedance
Head-Down Tilt
Dielectric Spectroscopy
Space Flight
Vasopressins
Hematocrit
Renin
Radioimmunoassay
Thorax
Hemodynamics
Head

Keywords

  • Aldosterone
  • Bed rest
  • Bioelectrical impedance spectroscopy
  • Cardiovascular
  • Extracellular fluid volume
  • Extracellular volume
  • Immobilization
  • Plasma renin activity
  • Renal function
  • Salt intake
  • Sodium excretion
  • Vasopressin

ASJC Scopus subject areas

  • Endocrinology

Cite this

Hinghofer-Szalakay, H. G., László, Z., Jezova, D., Rössler, A., Haditsch, B., Pilz, K., ... Scharfetter, H. (2002). Bed rest immobilization with various oral sodium supply: Plasma hormones and body fluids. Endocrine Regulations, 36(4), 151-159.

Bed rest immobilization with various oral sodium supply : Plasma hormones and body fluids. / Hinghofer-Szalakay, Helmut G.; László, Z.; Jezova, Daniela; Rössler, Andreas; Haditsch, Bernd; Pilz, Karl; Passath, Herfried; Scharfetter, Herman.

In: Endocrine Regulations, Vol. 36, No. 4, 11.2002, p. 151-159.

Research output: Contribution to journalArticle

Hinghofer-Szalakay, HG, László, Z, Jezova, D, Rössler, A, Haditsch, B, Pilz, K, Passath, H & Scharfetter, H 2002, 'Bed rest immobilization with various oral sodium supply: Plasma hormones and body fluids', Endocrine Regulations, vol. 36, no. 4, pp. 151-159.
Hinghofer-Szalakay HG, László Z, Jezova D, Rössler A, Haditsch B, Pilz K et al. Bed rest immobilization with various oral sodium supply: Plasma hormones and body fluids. Endocrine Regulations. 2002 Nov;36(4):151-159.
Hinghofer-Szalakay, Helmut G. ; László, Z. ; Jezova, Daniela ; Rössler, Andreas ; Haditsch, Bernd ; Pilz, Karl ; Passath, Herfried ; Scharfetter, Herman. / Bed rest immobilization with various oral sodium supply : Plasma hormones and body fluids. In: Endocrine Regulations. 2002 ; Vol. 36, No. 4. pp. 151-159.
@article{197a6c4ec31c4b5d97427581a7ca6eeb,
title = "Bed rest immobilization with various oral sodium supply: Plasma hormones and body fluids",
abstract = "Objective. To answer the question if plasma hormone concentrations (plasma renin activity PRA, vasopressin - pAVP, and aldosterone concentration) due to antiorthostatic immobilization (8 days -6° head-down tilt bed rest - HDBR) are altered by oral salt load, we provided constant sodium supply during 4 days ambulatory conditions followed by 8 days HDBR in 10 normotensive men. Methods. A,low' (LS: 143±10 mM) and,high' (HS: 434±17 mM Na+-/d excreted) sodium treatment were provided in randomized order, separated ≥1 mo. Before and at the end of HDBR, hemodynamic variables and thoracic impedance were determined, and blood was taken for aldosterone and PRA, venous hematocrit, and plasma mass density. Extracellular fluid volume and pAVP were determined every second day. Whole body electrical impedance spectroscopy was employed to assess changes in extracellular volume, hormone determinations were done with radioimmunoassay, mass density measurements with the mechanical oscillator technique. Results. Extracellular volume decreased with HDBR (LS: -4.0{\%}, p=0.002; HS: -5.8{\%}, p=0.018) without significant difference between salt treatments. Resting hormone levels were not altered by HDBR, but pAVP was lower (5.5±0.1 pg/ml) in HS than in LS (7.2±0.3 pg/ml) as was plasma aldosterone (HS: 69±7 pg/ml, LS: 180±24 pg/ml). On the other hand, HDBR reduced extracellular volume by ?5{\%} irrespective of dietary sodium supply. Conclusions. Our data support the hypothesis that hormonal activities are more affected by oral salt load than by simulated short-term space flight, and suggest that the reduction of extracellular fluid volume due to head down bed rest is not influenced by moderate changes of dietary sodium supply.",
keywords = "Aldosterone, Bed rest, Bioelectrical impedance spectroscopy, Cardiovascular, Extracellular fluid volume, Extracellular volume, Immobilization, Plasma renin activity, Renal function, Salt intake, Sodium excretion, Vasopressin",
author = "Hinghofer-Szalakay, {Helmut G.} and Z. L{\'a}szl{\'o} and Daniela Jezova and Andreas R{\"o}ssler and Bernd Haditsch and Karl Pilz and Herfried Passath and Herman Scharfetter",
year = "2002",
month = "11",
language = "English",
volume = "36",
pages = "151--159",
journal = "Endocrine Regulations",
issn = "1210-0668",
publisher = "Institute of Experimental Endocrinology",
number = "4",

}

TY - JOUR

T1 - Bed rest immobilization with various oral sodium supply

T2 - Plasma hormones and body fluids

AU - Hinghofer-Szalakay, Helmut G.

AU - László, Z.

AU - Jezova, Daniela

AU - Rössler, Andreas

AU - Haditsch, Bernd

AU - Pilz, Karl

AU - Passath, Herfried

AU - Scharfetter, Herman

PY - 2002/11

Y1 - 2002/11

N2 - Objective. To answer the question if plasma hormone concentrations (plasma renin activity PRA, vasopressin - pAVP, and aldosterone concentration) due to antiorthostatic immobilization (8 days -6° head-down tilt bed rest - HDBR) are altered by oral salt load, we provided constant sodium supply during 4 days ambulatory conditions followed by 8 days HDBR in 10 normotensive men. Methods. A,low' (LS: 143±10 mM) and,high' (HS: 434±17 mM Na+-/d excreted) sodium treatment were provided in randomized order, separated ≥1 mo. Before and at the end of HDBR, hemodynamic variables and thoracic impedance were determined, and blood was taken for aldosterone and PRA, venous hematocrit, and plasma mass density. Extracellular fluid volume and pAVP were determined every second day. Whole body electrical impedance spectroscopy was employed to assess changes in extracellular volume, hormone determinations were done with radioimmunoassay, mass density measurements with the mechanical oscillator technique. Results. Extracellular volume decreased with HDBR (LS: -4.0%, p=0.002; HS: -5.8%, p=0.018) without significant difference between salt treatments. Resting hormone levels were not altered by HDBR, but pAVP was lower (5.5±0.1 pg/ml) in HS than in LS (7.2±0.3 pg/ml) as was plasma aldosterone (HS: 69±7 pg/ml, LS: 180±24 pg/ml). On the other hand, HDBR reduced extracellular volume by ?5% irrespective of dietary sodium supply. Conclusions. Our data support the hypothesis that hormonal activities are more affected by oral salt load than by simulated short-term space flight, and suggest that the reduction of extracellular fluid volume due to head down bed rest is not influenced by moderate changes of dietary sodium supply.

AB - Objective. To answer the question if plasma hormone concentrations (plasma renin activity PRA, vasopressin - pAVP, and aldosterone concentration) due to antiorthostatic immobilization (8 days -6° head-down tilt bed rest - HDBR) are altered by oral salt load, we provided constant sodium supply during 4 days ambulatory conditions followed by 8 days HDBR in 10 normotensive men. Methods. A,low' (LS: 143±10 mM) and,high' (HS: 434±17 mM Na+-/d excreted) sodium treatment were provided in randomized order, separated ≥1 mo. Before and at the end of HDBR, hemodynamic variables and thoracic impedance were determined, and blood was taken for aldosterone and PRA, venous hematocrit, and plasma mass density. Extracellular fluid volume and pAVP were determined every second day. Whole body electrical impedance spectroscopy was employed to assess changes in extracellular volume, hormone determinations were done with radioimmunoassay, mass density measurements with the mechanical oscillator technique. Results. Extracellular volume decreased with HDBR (LS: -4.0%, p=0.002; HS: -5.8%, p=0.018) without significant difference between salt treatments. Resting hormone levels were not altered by HDBR, but pAVP was lower (5.5±0.1 pg/ml) in HS than in LS (7.2±0.3 pg/ml) as was plasma aldosterone (HS: 69±7 pg/ml, LS: 180±24 pg/ml). On the other hand, HDBR reduced extracellular volume by ?5% irrespective of dietary sodium supply. Conclusions. Our data support the hypothesis that hormonal activities are more affected by oral salt load than by simulated short-term space flight, and suggest that the reduction of extracellular fluid volume due to head down bed rest is not influenced by moderate changes of dietary sodium supply.

KW - Aldosterone

KW - Bed rest

KW - Bioelectrical impedance spectroscopy

KW - Cardiovascular

KW - Extracellular fluid volume

KW - Extracellular volume

KW - Immobilization

KW - Plasma renin activity

KW - Renal function

KW - Salt intake

KW - Sodium excretion

KW - Vasopressin

UR - http://www.scopus.com/inward/record.url?scp=0038298859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038298859&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 151

EP - 159

JO - Endocrine Regulations

JF - Endocrine Regulations

SN - 1210-0668

IS - 4

ER -