Beat-to-beat interplay of heart rate, ventricular depolarization, and repolarization

György Kozmann, Kristóf Haraszti, István Préda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To improve malignant arrhythmia risk stratification, the causal and random components of spatiotemporal dynamics of heart rate (RR distances), ventricular depolarization sequence, and repolarization disparity were studied based on body surface potential map records taken for 5 minutes, in resting, supine position on 14 healthy subjects (age range, 20-65 years) and on 6 arrhythmia patients (age range, 59-70 years). Beat-to-beat QRS and QRST integral maps, Karhunen-Loève (KL) coefficients, RR, and nondipolarity index time series were computed. Tight relationship was found between RR and QRS integrals in healthy subjects with less association in arrhythmia patients. Tight KL-domain multiple linear association (r2 > 0.72) was found between the QRS and QRST integral dynamics (ie, depolarization sequence and repolarization disparity). Beat-to-beat probability of the generation of significant nondipolarity index spikes was proportional to the QRST KL-component standard deviations (SDi) and inversely proportional with the mean dipolar KL components (Mi) of the average QRST integral map.

Original languageEnglish
Pages (from-to)15-24
Number of pages10
JournalJournal of Electrocardiology
Volume43
Issue number1
DOIs
Publication statusPublished - Jan 1 2010

Keywords

  • Arrhythmia vulnerability
  • Body surface potential maps
  • Depolarization sequence
  • Heart rate variability
  • Repolarization disparity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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