Basaloid carcinoma of the pancreas—clinicopathological presentation and oncogenetic snapshot of a rare entity

A. Marcell Szasz, Ildiko Szirtes, Balazs Tihanyi, Bernadett Barkaszi, Zsolt Baranyai, Tibor Tihanyi, Laszlo Harsanyi, Jozsef Timar, Janina Kulka

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

We report a case of basaloid pancreatic carcinoma with clinical, pathological, and genomic data. The 73-year-old male patient had jaundice, acholic stool, diarrhea, weight loss, and a large, painless gall bladder. His GGT was highly elevated. The pancreatic head contained a tumor, which was resected by partial pancreatoduodenectomy with pancreato-gastric anastomosis, cholecystectomy, and lymphadenectomy. On gross examination, a 3.8-cm white firm nodule was found, which microscopically was composed of basaloid cell nests with a less than usual desmoplastic stromal background and focally PANIN. Immunohistochemical profile displayed strong CK5/6, CK19, p63, EGFR, vimentin, and evident CK14 expression and absence of expression of CK7, chromogranin, synaptophysin, and BRCA1. A high Ki-67 index and p53 expression were noted. Sequencing of the most frequent 46 oncogenes with ionTorrent (AmpliSeq PCR) method identified PIK3CA, KRAS, and TP53 genes as drivers and variants of the FGFR3, PDGFRA, KIT, KDR, EGFR, RET, and ATM genes. The tumor we report displays histopathological appearances similar to the previously described case and a genomic landscape fitting to the general population of pancreatic carcinomas. We hypothesize that this tumor may belong to the group of DNA damage repair-deficient pancreatic carcinoma subgroup.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalVirchows Archiv
Volume466
Issue number2
DOIs
Publication statusPublished - Jan 1 2015

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Keywords

  • Basaloid
  • Carcinoma
  • Pancreas
  • Undifferentiated

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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