Basal cell carcinomas of the eyelid and the periorbital region

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Abstract

An electron microscopic study of 15 basal cell carcinomas of the eyelid and the periorbital region was performed. On the basis of their fine structural features and their junctions, the cells of the undifferentiated solid basal cell carcinoma were found to resemble the basal cells of normal epidermis. The characteristics of the basal carcinoma cells are the shift of the nucleus: plasma ratio in favor of the nucleus, a decreased amount of tonofibrils and of rough-surface endoplasmic reticulum, a decreased number of desmosomes and the absence of hemidesmosomes on the cell surface towards the basement membrane. The ultrastructural organization of the cells of the adenoid-type basal cell epitheliomas was essentially similar, but these showed signs of secretory activity. Hemidesmosomes were absent also in this type, but the lamina basalis was frequently developed not only around the cells but also on the cell surface towards the lumen. Transitional cell carcinomas were formed by 2 types of cell; the minority by cells similar to those of solid basal cell epithelioma, whereas the majority owing to their ample tonofibril-keratohyalin content and high number of desmosomes, was similar to the cells of the spinocellular layer. The cells of basosquamous keratinized epitheliomas were also similar to the cells of the spinocellular layer, but they displayed abnormal keratinization. In the 2 last-mentioned types, hemidesmosomes were present on the cell surface towards the basal membrane, and at some sites microinvasion was observed. The electron microscopic findings supported the origin of basal cell carcinoma from the basal layer of the epidermis and the various histologic types of basal cell carcinoma are considered to display the differentiation potential of basal cells into various directions.

Original languageEnglish
Pages (from-to)381-400
Number of pages20
JournalActa Morphologica Academiae Scientiarum Hungaricae
Volume24
Issue number4
Publication statusPublished - 1976

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Basal Cell Carcinoma
Eyelids
Hemidesmosomes
Desmosomes
Epidermis
Electrons
Carcinoma
Adenoids
Intercellular Junctions
Rough Endoplasmic Reticulum
Transitional Cell Carcinoma
Cell Nucleus
Basement Membrane

ASJC Scopus subject areas

  • Anatomy

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Basal cell carcinomas of the eyelid and the periorbital region. / Lapis, K.

In: Acta Morphologica Academiae Scientiarum Hungaricae, Vol. 24, No. 4, 1976, p. 381-400.

Research output: Contribution to journalArticle

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