Barrel rotation induced by central arginine8-vasopressin treatment: Involvement of neurohypophyseal peptide receptors

Michaela Diamant, Anne Marie Baars, G. Kovács, David de Wied

Research output: Contribution to journalArticle

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Abstract

Two series of experiments were done to investigate the mechanism underlying arginine8-vasopressin (AVP)-induced barrel rotation in rats. In the first series, the effect of intracerebroventricular (ICV) administration of various neurohypophyseal hormone antagonists on AVP-induced barrel rotation was studied. The more vasopressin was given, the more the rats exhibited barrel rotation. ICV pretreatment with a V1 vasopressin receptor antagonist, d(CH2)5[Tyr(Me)2]AVP, prevented barrel rotation, while similar treatment with a V2-antagonist, d(CH2)5[dIle2Ile4]AVP, did not affect vasopressin-induced barrel rotation. However, Des-Gly,NH2d(CH2)5[Tyr)Me2)Thr4Orn8]-vasotocin, a specific oxytocin antagonist, potentiated the effect of AVP on barrel rotation. The second experiment was performed in rats equipped with a telemetry system to measure heart rate (HR), core temperature (CT), and gross locomotor activity. Also, in this experiment the incidence of AVP-induced barrel rotation was dose-dependent, as was the number of rats that died. Barrel rotation was accompanied by a significant decrease in CT and HR, while rats that did not develop hypothermia did not show barrel rotation. These results suggest that a V1 receptor is involved in barrel rotation. Since AVP-induced hypothermia is also mediated by a V1 receptor, it is postulated that hypothermia is a prerequisite for barrel rotation to occur. Further experiments are needed to substantiate this hypothesis.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume47
Issue number1
DOIs
Publication statusPublished - 1994

Fingerprint

Posterior Pituitary Hormones
Peptide Receptors
Vasopressins
Hypothermia
Rats
Vasopressin Receptors
Therapeutics
Heart Rate
Experiments
Vasotocin
Hormone Antagonists
Induced Hypothermia
Telemetry
Temperature
Telemetering
Oxytocin
Locomotion

Keywords

  • Arginine-vasopressin
  • Barrel rotation
  • Core temperature
  • Heart rate
  • Receptors
  • Vasopressin receptor antagonists

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Barrel rotation induced by central arginine8-vasopressin treatment : Involvement of neurohypophyseal peptide receptors. / Diamant, Michaela; Baars, Anne Marie; Kovács, G.; de Wied, David.

In: Pharmacology, Biochemistry and Behavior, Vol. 47, No. 1, 1994, p. 27-32.

Research output: Contribution to journalArticle

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