Baroreflex sensitivity decreases with age

Data derived from a large population based study

A. Kardos, G. Watterich, Z. Gingl, M. Csanády, B. Casadei, L. Rudas

Research output: Contribution to journalArticle

Abstract

Background: Arterial baroreflex sensitivity (BRS) is a tool to assess the prognosis after myocardial infarction. Small studies suggested that BRS (by phenylephrine) declines with age. However, the normal values of the BRS in the population are not known. Objectives: We set out to define the relationship between age and BRS in a large population based study. Methods and Results: Four hundred and twenty healthy subjects (without positive medical history and free of medication) were selected from our database (237 m, 183 f). Subjects were divided into four age-groups; A: 19-29 y (121), B: 30-39 y (111) C: 40-49 y (101) D 50-59 y (87). BRS was evaluated by the slope of spontaneous changes in systolic blood pressure (BP) and R-R interval from 10 minutes BP (Finapres) and ECG recordings. Regression analysis was performed to assess the relationship between BRS and age, and the best fitting curve algorithm was applied (see Figure). Group averages were compared by ANOVA. There was a significant decrease in BRS with age (mean±SD, A: 16.3±7.9, B: 11.9±6.2, C: 8.8±4.8, D: 7.5±3.5 ms/mmHg, p

Original languageEnglish
JournalHeart
Volume79
Issue numberSUPPL. 1
Publication statusPublished - May 1998

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Baroreflex
Population
Blood Pressure
Phenylephrine
Analysis of Variance
Healthy Volunteers
Electrocardiography
Reference Values
Age Groups
Myocardial Infarction
Regression Analysis
Databases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Baroreflex sensitivity decreases with age : Data derived from a large population based study. / Kardos, A.; Watterich, G.; Gingl, Z.; Csanády, M.; Casadei, B.; Rudas, L.

In: Heart, Vol. 79, No. SUPPL. 1, 05.1998.

Research output: Contribution to journalArticle

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