Balancing act

Matching growth with environment by the TOR signalling pathway

Rossana Henriques, László Bögre, Beátrix Horváth, Z. Magyar

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

One of the most fundamental aspects of growth in plants is its plasticity in relation to fluctuating environmental conditions. Growth of meristematic cells relies predominantly on protein synthesis, one of the most energy-consuming activities in cells, and thus is tightly regulated in accordance with the available nutrient and energy supplies. The Target of Rapamycin (TOR) signalling pathway takes a central position in this regulation. The core of the TOR signalling pathway is conserved throughout evolution, and can be traced back to the last eukaryotic common ancestor. In plants, a single complex constitutes the TOR signalling pathway. Manipulating the components of the TOR complex in Arabidopsis highlighted its common role as a major regulator of protein synthesis and metabolism, that is also involved in other biological functions such as cell-wall integrity, regulation of cell proliferation, and cell size. TOR, as an integral part of the auxin signalling pathway, connects hormonal and nutrient pathways. Downstream of TOR, S6 kinase and the ribosomal S6 protein have been shown to mediate several of these responses, although there is evidence of other complex non-linear TOR signalling pathway structures.

Original languageEnglish
Pages (from-to)2691-2701
Number of pages11
JournalJournal of Experimental Botany
Volume65
Issue number10
DOIs
Publication statusPublished - 2014

Fingerprint

Sirolimus
protein synthesis
ribosomal proteins
energy
nutrients
Growth
protein metabolism
auxins
cell growth
cell proliferation
ancestry
phosphotransferases (kinases)
cell walls
Arabidopsis
plant growth
cells
environmental factors
Ribosomal Protein S6
Ribosomal Protein S6 Kinases
Food

Keywords

  • Cell proliferation
  • Cell size
  • Growth
  • Nutrient
  • Signalling
  • TOR

ASJC Scopus subject areas

  • Plant Science
  • Physiology

Cite this

Balancing act : Matching growth with environment by the TOR signalling pathway. / Henriques, Rossana; Bögre, László; Horváth, Beátrix; Magyar, Z.

In: Journal of Experimental Botany, Vol. 65, No. 10, 2014, p. 2691-2701.

Research output: Contribution to journalArticle

Henriques, Rossana ; Bögre, László ; Horváth, Beátrix ; Magyar, Z. / Balancing act : Matching growth with environment by the TOR signalling pathway. In: Journal of Experimental Botany. 2014 ; Vol. 65, No. 10. pp. 2691-2701.
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