Baker's yeast mediated reduction of dihydroxyacetone derivatives

J. Bálint, G. Egri, Attila Kolbert, Csilla Dianóczky, E. Fogassy, L. Novák, L. Poppe

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Several monoprotected dihydroxyacetone derivatives 4a-d and their acetates 5a-d were prepared and subjected to biotransformation with baker's yeast. The simple chemical modification of the substrates (i.e. transforming the relatively small hydrophilic hydroxymethyl group into a larger hydrophobic acetoxymethyl moiety) inverted the sense of enantiotope selectivity of these reductions yielding optically active diols 6a-d, or their enantiomeric acetates (7a-d) and diols (ent-6a-d), respectively.

Original languageEnglish
Pages (from-to)4017-4028
Number of pages12
JournalTetrahedron Asymmetry
Volume10
Issue number20
DOIs
Publication statusPublished - Oct 15 1999

Fingerprint

Dihydroxyacetone
yeast
Chemical modification
Yeast
Saccharomyces cerevisiae
acetates
Acetates
Derivatives
Substrates
Biotransformation
selectivity

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Baker's yeast mediated reduction of dihydroxyacetone derivatives. / Bálint, J.; Egri, G.; Kolbert, Attila; Dianóczky, Csilla; Fogassy, E.; Novák, L.; Poppe, L.

In: Tetrahedron Asymmetry, Vol. 10, No. 20, 15.10.1999, p. 4017-4028.

Research output: Contribution to journalArticle

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