A series of 10-alkyl-10H-phenothiazine-3-carbaldehydes (2a-h) were obtained by Vilsmeier-Haack formylation from the corresponding 10-alkyl-10H-phenothiazines (1a-h) and reduced to (10-alkyl-10H-phenothiazine-3-yl)methanols (3a-h) by two alternative methods. The baker's yeast catalyzed reaction proved to be superior over the NaBH4 reduction and yielded the desired 3-hydroxymethylphenothiazines (3a-h) almost quantitatively.
- Baker's yeast
ASJC Scopus subject areas
- Process Chemistry and Technology