Baker's yeast mediated preparation of (10-alkyl-10H-phenothiazin-3-yl)methanols

Monica Toşa, Csaba Paizs, Cornelia Majdik, Paula Moldovan, Lajos Novák, Pál Kolonits, Éva Szabó, László Poppe, Florin Dan Irimie

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A series of 10-alkyl-10H-phenothiazine-3-carbaldehydes (2a-h) were obtained by Vilsmeier-Haack formylation from the corresponding 10-alkyl-10H-phenothiazines (1a-h) and reduced to (10-alkyl-10H-phenothiazine-3-yl)methanols (3a-h) by two alternative methods. The baker's yeast catalyzed reaction proved to be superior over the NaBH4 reduction and yielded the desired 3-hydroxymethylphenothiazines (3a-h) almost quantitatively.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalJournal of Molecular Catalysis - B Enzymatic
Volume17
Issue number6
DOIs
Publication statusPublished - Jul 17 2002

Keywords

  • Aldehydes
  • Baker's yeast
  • Formylation
  • N-alkylphenothiazines
  • Reduction

ASJC Scopus subject areas

  • Catalysis
  • Bioengineering
  • Biochemistry
  • Process Chemistry and Technology

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