BAG-1 induces autophagy for cardiac cell survival

Narasimman Gurusamy, I. Lekli, Mihaela Gherghiceanu, Lawrence M. Popescu, Dipak K. Das

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The Bcl-2 associated athanogene (BAG) family of proteins function as cochaperones by bridging molecules that recruit molecular chaperones to target proteins. BAG-1 provides a physical link between the heat shock proteins Hsc70/Hsp70 and the proteasome to facilitate ubiquitin-proteasome-mediated protein degradation. In addition to the proteasome, protein degradation via autophagy is responsible for maintaining cellular metabolism, organelle homeostasis and redox equilibrium. Our recent report shows that autophagy plays an important role in cardiac adaptation-induced cell survival against ischemia-reperfusion injury in association with the BAG-1 protein. BAG-1 is associated with the autophagosomal membrane protein LC3-II and it may participate in the induction of autophagy via Hsc70. Moreover, another BAG family member, BAG-3, is responsible for the induction of macroautophagy in association with HspB8. These results show the involvement of BAG family members in the induction of autophagy for the degradation of damaged or oxidized proteins to promote cell survival.

Original languageEnglish
Pages (from-to)120-121
Number of pages2
JournalAutophagy
Volume5
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

Fingerprint

Autophagy
Cell Survival
Proteasome Endopeptidase Complex
Proteolysis
Proteins
Molecular Chaperones
Ubiquitin
Heat-Shock Proteins
Reperfusion Injury
Organelles
Oxidation-Reduction
Membrane Proteins
Homeostasis

Keywords

  • Autophagy
  • BAG-1
  • Cardiac adaptation
  • Cell survival
  • Heat shock protein
  • LC3
  • Protein degradation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Gurusamy, N., Lekli, I., Gherghiceanu, M., Popescu, L. M., & Das, D. K. (2009). BAG-1 induces autophagy for cardiac cell survival. Autophagy, 5(1), 120-121. https://doi.org/10.1111/j.1582-4934.2008.00495.x

BAG-1 induces autophagy for cardiac cell survival. / Gurusamy, Narasimman; Lekli, I.; Gherghiceanu, Mihaela; Popescu, Lawrence M.; Das, Dipak K.

In: Autophagy, Vol. 5, No. 1, 01.01.2009, p. 120-121.

Research output: Contribution to journalArticle

Gurusamy, N, Lekli, I, Gherghiceanu, M, Popescu, LM & Das, DK 2009, 'BAG-1 induces autophagy for cardiac cell survival', Autophagy, vol. 5, no. 1, pp. 120-121. https://doi.org/10.1111/j.1582-4934.2008.00495.x
Gurusamy N, Lekli I, Gherghiceanu M, Popescu LM, Das DK. BAG-1 induces autophagy for cardiac cell survival. Autophagy. 2009 Jan 1;5(1):120-121. https://doi.org/10.1111/j.1582-4934.2008.00495.x
Gurusamy, Narasimman ; Lekli, I. ; Gherghiceanu, Mihaela ; Popescu, Lawrence M. ; Das, Dipak K. / BAG-1 induces autophagy for cardiac cell survival. In: Autophagy. 2009 ; Vol. 5, No. 1. pp. 120-121.
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