Bacterial biofilm formation on urologic devices and heparin coating as preventive strategy

Peter Tenke, Claus R. Riedl, Gwennan Ll Jones, Gareth J. Williams, David Stickler, Elisabeth Nagy

Research output: Contribution to journalArticle

110 Citations (Scopus)


In the process of endourological development a variety of foreign bodies have been invented besides urinary catheters, on which biofilm can be formed. Bacteria in the biofilm are less susceptible to antibiotics. An additional problem of medical biomaterials in the urinary tract environment is the development of encrustation and consecutive obstruction. The most promising prevention strategy for bacterial biofilms is the production of materials with anti-adhesive surfaces such as heparin. Although heparin-coated ureteral stents are expensive, they justify their cost. Our studies show that such devices are protected against incrustation and biofilm formation for a longer period of time: 6-12 months, both in vitro and in vivo.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalInternational Journal of Antimicrobial Agents
Issue numberSUPPL. 1
Publication statusPublished - Mar 2004


  • Antimicrobial susceptibility
  • Biofilm formation
  • Heparin coating
  • Incrustation
  • Obstruction

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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