B and T cell markers of bone marrow and peripheral blood lymphoid cells in patients with paraproteinaemia

S. Husz, F. Krizsa, A. Dobozy, J. Hunyadi, N. Simon

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Abstract

Studies were carried out on B and T cells in bone marrow and peripheral blood from patients with paraproteinaemia. The peripheral blood of patients with multiple myeloma showed a significant increase of B cells, mainly lymphoid cells bearing immunoglobulins corresponding to the paraproteins, while in patients with benign monoclonal gammopathy only a slight increase of B cells and a moderate decrease of T cells have been found. As to the bone marrow, the B cell population was significantly raised in patients with multiple myeloma, but it remained unchanged in patients with benign monoclonal gammopathy. Our findings may offer a new possibility to distinguish between these two diseases and provide further data to their pathogenesis.

Original languageEnglish
Pages (from-to)321-330
Number of pages10
JournalActa Haematologica
Volume57
Issue number6
Publication statusPublished - 1977

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Paraproteinemias
Blood Cells
B-Lymphocytes
Bone Marrow
Lymphocytes
T-Lymphocytes
Monoclonal Gammopathy of Undetermined Significance
Multiple Myeloma
Paraproteins
Bone Marrow Cells
Immunoglobulins
Population

ASJC Scopus subject areas

  • Hematology

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B and T cell markers of bone marrow and peripheral blood lymphoid cells in patients with paraproteinaemia. / Husz, S.; Krizsa, F.; Dobozy, A.; Hunyadi, J.; Simon, N.

In: Acta Haematologica, Vol. 57, No. 6, 1977, p. 321-330.

Research output: Contribution to journalArticle

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