Azidoethylmorphine (3-ethoxy-6-deoxy-6-azido-dihydroisomorphine) has a specifically potent antitussive activity in experimentally induced coughing. The antitussive potency of the drug was found to be 60 times higher than that of codeine in the rat after oral administration. The compound given intravenously had a strong analgesic activity being 7.8 times more potent in this respect than codeine in the rat. The therapeutic index of azidoethylmorphine as compared to that of codeine proved to be much more favorable. Azidoethylmorphine applied in antitussive doses failed to depress respiration and did not change the acid-base balance. The intravenous cough depressing dose of azidoethylmorphine did not affect mean arterial blood pressure in the cat. Adverse side effects such as constipation, tolerance and physical dependence liability were induced much less by azidoethylmorphine than by codeine.
|Number of pages||16|
|Journal||Acta physiologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Jan 1 1977|
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