Azidoethylmorphine, a new potent, non-narcotic oral antitussive

J. Knoll, L. G. Harsing, T. Friedmann

Research output: Contribution to journalArticle

Abstract

Azidoethylmorphine (3-ethoxy-6-deoxy-6-azido-dihydroisomorphine) has a specifically potent antitussive activity in experimentally induced coughing. The antitussive potency of the drug was found to be 60 times higher than that of codeine in the rat after oral administration. The compound given intravenously had a strong analgesic activity being 7.8 times more potent in this respect than codeine in the rat. The therapeutic index of azidoethylmorphine as compared to that of codeine proved to be much more favorable. Azidoethylmorphine applied in antitussive doses failed to depress respiration and did not change the acid-base balance. The intravenous cough depressing dose of azidoethylmorphine did not affect mean arterial blood pressure in the cat. Adverse side effects such as constipation, tolerance and physical dependence liability were induced much less by azidoethylmorphine than by codeine.

Original languageEnglish
Pages (from-to)341-356
Number of pages16
JournalActa physiologica Academiae Scientiarum Hungaricae
Volume50
Issue number3
Publication statusPublished - Jan 1 1977

ASJC Scopus subject areas

  • Physiology

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