Axovascular relationships in developing median eminence of perinatal rats with special reference to luteinizing hormone-releasing hormone projections

M. V. Ugrumov, I. P. Ivanova, M. S. Mitskevich, Z. Liposits, G. Sétáló, B. Flerkó

Research output: Contribution to journalArticle

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Abstract

Topographical relationships of neurosecretory axons with the capillaries of the primary portal plexus were studied in the median eminence of rats from the 14th fetal till the 9th postnatal day by means of electron microscopy combined with morphometric analysis. Special attention was given to the light and electron microscopic immunocytochemical examination of luteinizing hormone-releasing hormone projections to the median eminence. Neurosecretory axons possessing secretory granules and clear microvesicles were first observed in the median eminence at the 14th fetal day. However, all of them were situated at a distance from the primary portal plexus. By the 20th fetal day, neurosecretory axons reached the external basal lamina of the primary portal plexus giving rise to so-called axovascular contacts. Some axons even penetrated into the perivascular space, apparently facilitating the neurohormone delivery into the hypophysial portal circulation. From that time on, both the number of the axons abutting on the external basal lamina and the entire area of axovascular contacts increased gradually. As to luteinizing hormone-releasing hormone axons, they grew into the median eminence from the 18th fetal day concentrating in older fetuses and neonates either over the primary portal plexus, or around the infundibular recess of the 3rd ventricle. After birth, the concentration and distribution of luteinizing hormone-releasing hormone axons within the median eminence became similar to those of adults. Luteinizing hormone-releasing hormone axons were found to arise from the neurons of septopreoptic area including the diagonal band of Broca. These data suggest the onset of neurohormone release in the median eminence from the 14th fetal day followed by the establishment of the hypothalamic control over the pituitary functions during the perinatal period in rats.

Original languageEnglish
Pages (from-to)897-906
Number of pages10
JournalNeuroscience
Volume16
Issue number4
DOIs
Publication statusPublished - 1985

Fingerprint

Median Eminence
Gonadotropin-Releasing Hormone
Axons
Basement Membrane
Neurotransmitter Agents
Diagonal Band of Broca
Third Ventricle
Secretory Vesicles
Electron Microscopy
Fetus
Parturition
Electrons
Neurons
Light

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Axovascular relationships in developing median eminence of perinatal rats with special reference to luteinizing hormone-releasing hormone projections. / Ugrumov, M. V.; Ivanova, I. P.; Mitskevich, M. S.; Liposits, Z.; Sétáló, G.; Flerkó, B.

In: Neuroscience, Vol. 16, No. 4, 1985, p. 897-906.

Research output: Contribution to journalArticle

Ugrumov, M. V. ; Ivanova, I. P. ; Mitskevich, M. S. ; Liposits, Z. ; Sétáló, G. ; Flerkó, B. / Axovascular relationships in developing median eminence of perinatal rats with special reference to luteinizing hormone-releasing hormone projections. In: Neuroscience. 1985 ; Vol. 16, No. 4. pp. 897-906.
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