Axonal labyrinths in the rat spinal cord: a consequence of degenerative atrophy

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Transection, crush or local colchicine treatment of a peripheral nerve induces degenerative atrophy of central terminals of primary sensory neurons in the Rolandic substance of the rat spinal cord. In addition, to osmiophilic alterations that occur in the course of degenerative processes in general, degenerative atrophy is characterized by the appearance of spectacular labyrinthine formations. Electron-microscopic analysis reveals that these consist of flattened axonal profiles. Axonal labyrinths are interpreted as signs of futile regenerative efforts of axon terminals undergoing degenerative atrophy. Labyrinths disappear from the Rolandic substance several months after peripheral nerve injury, when degenerative atrophy of the central terminal is replaced by regenerative proliferation.

Original languageEnglish
Pages (from-to)299-308
Number of pages10
JournalActa biologica Academiae Scientiarum Hungaricae
Issue number4
Publication statusPublished - Dec 1 1976

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

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