Avian pancreatic polypeptide (APP) immunoreactive neurons in the spinal cord and spinal trigeminal nucleus

Tomas Hökfelt, Jan M. Lundberg, Lars Terenius, Gabor Jancsó, Joe Kimmel

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Using indirect immunofluorescence technique, avian pancreatic polypeptide (APP) immunoreactive cell bodies and fibres have been observed in the superficial laminae of the dorsal horn of the spinal cord and of the spinal trigeminal nucleus. Fibres were also seen in the ventral horns, in low numbers at the cervical and thoracic levels and in high numbers at the lower lumbar and upper sacral levels. Neither total cord transection, nor dorsal rhizotomy, nor capsaicin treatment seemed to affect the APP systems described above. The present findings suggest that an APP-like peptide may be involved in processing of sensory information at the level of the first relay station.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalPeptides
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 1 1981

Keywords

  • APP
  • Immunoreactive neurons
  • Spinal cord
  • Spinal trigeminal nucleus

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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