Avian pancreatic polypeptide (APP) immunoreactive neurons in the spinal cord and spinal trigeminal nucleus

Tomas Hökfelt, Jan M. Lundberg, Lars Terenius, G. Jancsó, Joe Kimmel

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Using indirect immunofluorescence technique, avian pancreatic polypeptide (APP) immunoreactive cell bodies and fibres have been observed in the superficial laminae of the dorsal horn of the spinal cord and of the spinal trigeminal nucleus. Fibres were also seen in the ventral horns, in low numbers at the cervical and thoracic levels and in high numbers at the lower lumbar and upper sacral levels. Neither total cord transection, nor dorsal rhizotomy, nor capsaicin treatment seemed to affect the APP systems described above. The present findings suggest that an APP-like peptide may be involved in processing of sensory information at the level of the first relay station.

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalPeptides
Volume2
Issue number1
DOIs
Publication statusPublished - 1981

Fingerprint

Spinal Trigeminal Nucleus
Neurons
Spinal Cord
Pancreatic Polypeptide-Secreting Cells
Rhizotomy
Fibers
Capsaicin
Indirect Fluorescent Antibody Technique
Horns
Automatic Data Processing
Thorax
Cells
Peptides
Processing
avian pancreatic polypeptide
Therapeutics

Keywords

  • APP
  • Immunoreactive neurons
  • Spinal cord
  • Spinal trigeminal nucleus

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Avian pancreatic polypeptide (APP) immunoreactive neurons in the spinal cord and spinal trigeminal nucleus. / Hökfelt, Tomas; Lundberg, Jan M.; Terenius, Lars; Jancsó, G.; Kimmel, Joe.

In: Peptides, Vol. 2, No. 1, 1981, p. 81-87.

Research output: Contribution to journalArticle

Hökfelt, Tomas ; Lundberg, Jan M. ; Terenius, Lars ; Jancsó, G. ; Kimmel, Joe. / Avian pancreatic polypeptide (APP) immunoreactive neurons in the spinal cord and spinal trigeminal nucleus. In: Peptides. 1981 ; Vol. 2, No. 1. pp. 81-87.
@article{668e57f6d2684bb88498e0a0cee58a74,
title = "Avian pancreatic polypeptide (APP) immunoreactive neurons in the spinal cord and spinal trigeminal nucleus",
abstract = "Using indirect immunofluorescence technique, avian pancreatic polypeptide (APP) immunoreactive cell bodies and fibres have been observed in the superficial laminae of the dorsal horn of the spinal cord and of the spinal trigeminal nucleus. Fibres were also seen in the ventral horns, in low numbers at the cervical and thoracic levels and in high numbers at the lower lumbar and upper sacral levels. Neither total cord transection, nor dorsal rhizotomy, nor capsaicin treatment seemed to affect the APP systems described above. The present findings suggest that an APP-like peptide may be involved in processing of sensory information at the level of the first relay station.",
keywords = "APP, Immunoreactive neurons, Spinal cord, Spinal trigeminal nucleus",
author = "Tomas H{\"o}kfelt and Lundberg, {Jan M.} and Lars Terenius and G. Jancs{\'o} and Joe Kimmel",
year = "1981",
doi = "10.1016/S0196-9781(81)80015-0",
language = "English",
volume = "2",
pages = "81--87",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Avian pancreatic polypeptide (APP) immunoreactive neurons in the spinal cord and spinal trigeminal nucleus

AU - Hökfelt, Tomas

AU - Lundberg, Jan M.

AU - Terenius, Lars

AU - Jancsó, G.

AU - Kimmel, Joe

PY - 1981

Y1 - 1981

N2 - Using indirect immunofluorescence technique, avian pancreatic polypeptide (APP) immunoreactive cell bodies and fibres have been observed in the superficial laminae of the dorsal horn of the spinal cord and of the spinal trigeminal nucleus. Fibres were also seen in the ventral horns, in low numbers at the cervical and thoracic levels and in high numbers at the lower lumbar and upper sacral levels. Neither total cord transection, nor dorsal rhizotomy, nor capsaicin treatment seemed to affect the APP systems described above. The present findings suggest that an APP-like peptide may be involved in processing of sensory information at the level of the first relay station.

AB - Using indirect immunofluorescence technique, avian pancreatic polypeptide (APP) immunoreactive cell bodies and fibres have been observed in the superficial laminae of the dorsal horn of the spinal cord and of the spinal trigeminal nucleus. Fibres were also seen in the ventral horns, in low numbers at the cervical and thoracic levels and in high numbers at the lower lumbar and upper sacral levels. Neither total cord transection, nor dorsal rhizotomy, nor capsaicin treatment seemed to affect the APP systems described above. The present findings suggest that an APP-like peptide may be involved in processing of sensory information at the level of the first relay station.

KW - APP

KW - Immunoreactive neurons

KW - Spinal cord

KW - Spinal trigeminal nucleus

UR - http://www.scopus.com/inward/record.url?scp=0019475084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019475084&partnerID=8YFLogxK

U2 - 10.1016/S0196-9781(81)80015-0

DO - 10.1016/S0196-9781(81)80015-0

M3 - Article

VL - 2

SP - 81

EP - 87

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 1

ER -