Avemar (wheat germ extract) in cancer prevention and treatment.

András Telekes, Márta Hegedus, Chang Hoon Chae, K. Vékey

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Many healthy foods are derived from wheat germ. The molecular composition of these products, however, greatly differs as shown by normal-phase HPLC-mass spectrometry analysis; thus, experimental data obtained by one of them is not necessarily true for the other. Avemar is a nontoxic wheat germ extract registered as a special nutriment for cancer patients in Hungary. It shows potent anticancer activity on cell lines by deeply interfering with glucose metabolism and affecting expressions of several kinases. In in vivo experimental models, Avemar is also effective by enhancing the activity of the immune system such as stimulating NK cell activity (by reducing MHC I molecule expression), enhancing TNF secretion of the macrophages, increasing ICAM 1 molecule expression on the vascular endothelial cells. All of these lead to apoptosis of tumor cells. The wide range of biological activity of Avemar probably cannot be explained by only one active ingredient. Since there are numerous experimental data and the clinical benefit repeatedly confirmed Avemar can be one of the most potent and best researched food supplements available for cancer patients.

Original languageEnglish
Pages (from-to)891-899
Number of pages9
JournalNutrition and Cancer
Volume61
Issue number6
DOIs
Publication statusPublished - Nov 2009

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Triticum
Neoplasms
Hungary
Intercellular Adhesion Molecule-1
Therapeutics
Dietary Supplements
Natural Killer Cells
Immune System
Mass Spectrometry
Theoretical Models
Phosphotransferases
Endothelial Cells
Macrophages
High Pressure Liquid Chromatography
Apoptosis
Glucose
Cell Line
Food
Avemar

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Avemar (wheat germ extract) in cancer prevention and treatment. / Telekes, András; Hegedus, Márta; Chae, Chang Hoon; Vékey, K.

In: Nutrition and Cancer, Vol. 61, No. 6, 11.2009, p. 891-899.

Research output: Contribution to journalArticle

Telekes, András ; Hegedus, Márta ; Chae, Chang Hoon ; Vékey, K. / Avemar (wheat germ extract) in cancer prevention and treatment. In: Nutrition and Cancer. 2009 ; Vol. 61, No. 6. pp. 891-899.
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