Autophagy, myocardial protection, and the metabolic syndrome

Zoltan Giricz, Robert M. Mentzer, Roberta A. Gottlieb

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Autophagy is a housekeeping process that helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given the evidence that autophagy is suppressed in energy-rich conditions, the objective of this review is to examine autophagy and cardioprotection in the setting of the metabolic syndrome. Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart's tolerance to ischemia are also discussed.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalJournal of cardiovascular pharmacology
Volume60
Issue number2
DOIs
Publication statusPublished - Aug 1 2012

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Keywords

  • autophagy
  • cardioprotection
  • metabolic syndrome
  • myocardial ischemia and reperfusion

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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