Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans

István Aladzsity, Márton L. Tóth, Tímea Sigmond, Emese Szabó, Bertalan Bicsák, János Barna, Ágnes Regos, L. Orosz, A. Kovács, T. Vellai

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Here we show that in the nematode Caenorhabditis elegans mutational inactivation of two autophagy genes unc-51/atg1 and bec-1/atg6/beclin1 results in small body size without affecting cell number. Furthermore, loss-of-function mutations in unc-51 and bec-1 suppress the giant phenotype of mutant animals with aberrant insulin-like growth factor-1 (insulin/IGF-1) or transforming growth factor-β (TGF-β) signaling. This function for unc-51 and bec-1 in cell size control and their interaction with these two growth modulatory pathways may represent a link between the hormonal and nutritional regulation of cell growth.

Original languageEnglish
Pages (from-to)655-660
Number of pages6
JournalGenetics
Volume177
Issue number1
DOIs
Publication statusPublished - Sep 2007

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Autophagy
Caenorhabditis elegans
Cell Size
Body Size
Transforming Growth Factors
Somatomedins
Growth
Insulin-Like Growth Factor I
Genes
Cell Count
Insulin
Phenotype
Mutation
Beclin-1

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Aladzsity, I., Tóth, M. L., Sigmond, T., Szabó, E., Bicsák, B., Barna, J., ... Vellai, T. (2007). Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans. Genetics, 177(1), 655-660. https://doi.org/10.1534/genetics.107.075762

Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans. / Aladzsity, István; Tóth, Márton L.; Sigmond, Tímea; Szabó, Emese; Bicsák, Bertalan; Barna, János; Regos, Ágnes; Orosz, L.; Kovács, A.; Vellai, T.

In: Genetics, Vol. 177, No. 1, 09.2007, p. 655-660.

Research output: Contribution to journalArticle

Aladzsity, I, Tóth, ML, Sigmond, T, Szabó, E, Bicsák, B, Barna, J, Regos, Á, Orosz, L, Kovács, A & Vellai, T 2007, 'Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans', Genetics, vol. 177, no. 1, pp. 655-660. https://doi.org/10.1534/genetics.107.075762
Aladzsity I, Tóth ML, Sigmond T, Szabó E, Bicsák B, Barna J et al. Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans. Genetics. 2007 Sep;177(1):655-660. https://doi.org/10.1534/genetics.107.075762
Aladzsity, István ; Tóth, Márton L. ; Sigmond, Tímea ; Szabó, Emese ; Bicsák, Bertalan ; Barna, János ; Regos, Ágnes ; Orosz, L. ; Kovács, A. ; Vellai, T. / Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans. In: Genetics. 2007 ; Vol. 177, No. 1. pp. 655-660.
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