Automatic Segmentation and Quantitative Analysis of Irradiated Zebrafish Embryos

Melinda Katona, Tünde Tőkés, Emília Rita Szabó, Szilvia Brunner, Imre Zoltán Szabó, Róbert Polanek, Katalin Hideghéty, L. Nyúl

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Radiotherapy is one of the most common methods to treat different cancer cells in clinical application despite having harmful effects on healthy tissues. Radiobiological experiments are very important to determine the irradiation-caused acute and chronic effects to define the exact consequences of different irradiation sources. Photon irradiation has been used on zebrafish embryos, a very new in vivo and appropriate model system in radiobiology. After irradiation, dose-dependent morphological changes were observable in the embryos. These morphological deteriorations were measured manually by biologist researchers during three weeks, which was an extremely time demanding process (15 min per image). The aim of this project was to automate this evaluating process, to save time for researchers and to keep the consistence and accuracy of the evaluation. Hence, an algorithm was developed and used to detect the abnormal development of zebrafish embryos.

Original languageEnglish
Title of host publicationComputational Modeling of Objects Presented in Images. Fundamentals, Methods, and Applications - 6th International Conference, CompIMAGE 2018, Revised Selected Papers
EditorsReneta P. Barneva, Valentin E. Brimkov, Piotr Kulczycki, Valentin E. Brimkov, João Manuel R.S. Tavares
PublisherSpringer Verlag
Pages95-107
Number of pages13
ISBN (Print)9783030208042
DOIs
Publication statusPublished - Jan 1 2019
Event6th International Symposium on Computational Modeling of Objects Presented in Images, CompIMAGE 2018 - Cracow, Poland
Duration: Jul 2 2018Jul 5 2018

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10986 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference6th International Symposium on Computational Modeling of Objects Presented in Images, CompIMAGE 2018
CountryPoland
CityCracow
Period7/2/187/5/18

Keywords

  • Deterioration
  • Gamma-irradiation
  • Image segmentation
  • Morphology
  • Quantitative analysis
  • Zebrafish

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Katona, M., Tőkés, T., Szabó, E. R., Brunner, S., Szabó, I. Z., Polanek, R., Hideghéty, K., & Nyúl, L. (2019). Automatic Segmentation and Quantitative Analysis of Irradiated Zebrafish Embryos. In R. P. Barneva, V. E. Brimkov, P. Kulczycki, V. E. Brimkov, & J. M. R. S. Tavares (Eds.), Computational Modeling of Objects Presented in Images. Fundamentals, Methods, and Applications - 6th International Conference, CompIMAGE 2018, Revised Selected Papers (pp. 95-107). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10986 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-030-20805-9_9