Autológ hemopoetikus őssejt- transzplantáció eredményei chronicus myeloid leukaemiában

Gopcsa László, Barta Anikó, Bányai Anikó, Földi János, Kalász László, Pajor László, Gidáli Júlia, Pálóczi Katalin

Research output: Contribution to journalArticle

Abstract

For most chronic myeloid leukaemia patients the option of a potentially curative allogeneic stem cell transplantation is not available because of age or lack of donor. Alternative therapy with interferon-alpha appears to prolong survival but is probably not curative. The aim of the study is to analyse the clinical results of the first Hungarian autologous transplantations in CML. Methods: Seven patients were treated with ICE-based regimen plus G-CSF with the aim of mobilising and collecting Ph-negative peripheral stem cells in the setting of autologous transplant program. Five patients had CML in first chronic phase and two in accelerated phase. All patients have been previously treated with interferonalpha. Results: Median value and ranges for harvested mononuclear cells, CD34+ cells and CFU-GM were: 5.65×108/kg (2.61-11.38), 1.48×106/kg (0.216-3.5) and 3.43×10 4/kg (0.243-11.6), respectively. Four out of seven autologous grafts have been transplanted. Busulfan conditioning was used in one case and TBI/Cy conditioning in three patients. All patients are alive and well post-transplant being on interferon-alpha therapy. Conclusions: Based on the clinical advantages of autologous transplantation including long-term chronic phase, achievement of second chronic phase and improved response to interferon-alpha therapy, the procedure can offer an alternative treatment in CML in lack of HLA-identical donor.

Original languageHungarian
Pages (from-to)9-13
Number of pages5
JournalMagyar onkologia
Volume45
Issue number1
Publication statusPublished - Jan 1 2001

ASJC Scopus subject areas

  • Medicine(all)

Cite this

László, G., Anikó, B., Anikó, B., János, F., László, K., László, P., Júlia, G., & Katalin, P. (2001). Autológ hemopoetikus őssejt- transzplantáció eredményei chronicus myeloid leukaemiában. Magyar onkologia, 45(1), 9-13.