Autoimmunity and ALS

R. G. Smith, L. Siklós, M. E. Alexianu, J. Engelhardt, D. R. Mosier, L. Colom, A. Habib Mohamed, S. H. Appel

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Significant evidence has accrued suggesting that antibodies to voltage- gated calcium channel are observed in at least some patients with sporadic ALS (SALS) and that such antibodies alter the function of these ion channels in vitro and in vivo. Further, passive transfer of these immunoglobulin- containing fractions into mice produces changes at the neuromuscular junction that are very similar to changes observed in patients with SALS. These changes reflect local alterations in intracellular Ca2+ homeostasis and, in animal models, may also evidence early changes of motoneuron injury, such as Golgi apparatus swelling and fragmentation. Although not yet documented to induce motoneuron death in vivo, SALS immunoglobulins induce Ca2+- dependent apoptosis in a differentiated motoneuron hybrid cell line via a mechanism that involves oxidative injury. SALS immunoglobulin-mediated apoptosis in these cells is regulated by the presence of the same calcium- binding proteins that may modulate selective motoneuron vulnerability in SALS.

Original languageEnglish
JournalNeurology
Volume47
Issue number4 SUPPL.
Publication statusPublished - Oct 1996

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Motor Neurons
Autoimmunity
Immunoglobulins
Apoptosis
Calcium-Binding Proteins
Antibodies
Hybrid Cells
Neuromuscular Junction
Wounds and Injuries
Golgi Apparatus
Calcium Channels
Ion Channels
Homeostasis
Animal Models
Cell Line

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Smith, R. G., Siklós, L., Alexianu, M. E., Engelhardt, J., Mosier, D. R., Colom, L., ... Appel, S. H. (1996). Autoimmunity and ALS. Neurology, 47(4 SUPPL.).

Autoimmunity and ALS. / Smith, R. G.; Siklós, L.; Alexianu, M. E.; Engelhardt, J.; Mosier, D. R.; Colom, L.; Mohamed, A. Habib; Appel, S. H.

In: Neurology, Vol. 47, No. 4 SUPPL., 10.1996.

Research output: Contribution to journalArticle

Smith, RG, Siklós, L, Alexianu, ME, Engelhardt, J, Mosier, DR, Colom, L, Mohamed, AH & Appel, SH 1996, 'Autoimmunity and ALS', Neurology, vol. 47, no. 4 SUPPL..
Smith RG, Siklós L, Alexianu ME, Engelhardt J, Mosier DR, Colom L et al. Autoimmunity and ALS. Neurology. 1996 Oct;47(4 SUPPL.).
Smith, R. G. ; Siklós, L. ; Alexianu, M. E. ; Engelhardt, J. ; Mosier, D. R. ; Colom, L. ; Mohamed, A. Habib ; Appel, S. H. / Autoimmunity and ALS. In: Neurology. 1996 ; Vol. 47, No. 4 SUPPL.
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