Autocrine regulation of murine B lymphocyte growth by an IgM antibody

F. Uher, M. E. Alonso, R. Mihalik, E. Balogh, J. Gergely

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Culture supernatants of LPS-stimulated murine B lymphocytes are able to inhibit the growth of freshly isolated splenic B cells via an IgM antibody. Tile binding specificity of this IgM is not yet defined, but appears to be a B lymphocyte surface structure distinct from membrane immunoglobulin, MHC class II antigen, transferrin and Fcγ receptors, and B220. The regulatory autoantibody allows the normal progression of early, but not late steps in the cycle of polyclonally-stimulated B lymphocytes and does not affect the increased antigen-presenting capacity of activated B cells. Therefore, this autoregulatory cycle is apparently ubiquitous and may be a major component of B lymphocyte homeostasis under physiological, as well as pathological conditions. Moreover, these findings bring into focus a possible regulating role of B lymphocytes in the humoral immune response.

Original languageEnglish
Pages (from-to)292-302
Number of pages11
JournalImmunobiology
Volume185
Issue number2-4
Publication statusPublished - 1992

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Immunoglobulin M
B-Lymphocytes
Antibodies
Growth
Antigen Receptors
Transferrin Receptors
Fc Receptors
Immunoglobulin Isotypes
Histocompatibility Antigens Class II
Humoral Immunity
Autoantibodies
Homeostasis
Antigens
Membranes

ASJC Scopus subject areas

  • Immunology

Cite this

Autocrine regulation of murine B lymphocyte growth by an IgM antibody. / Uher, F.; Alonso, M. E.; Mihalik, R.; Balogh, E.; Gergely, J.

In: Immunobiology, Vol. 185, No. 2-4, 1992, p. 292-302.

Research output: Contribution to journalArticle

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