Autocrine and paracrine regulation by cytokines and growth factors in melanoma

Eszter Lázár-Molnár, H. Hegyesi, S. Tóth, A. Falus

Research output: Contribution to journalArticle

335 Citations (Scopus)

Abstract

Tumour development and progression involves the expression of oncogenes and inactivation of tumour suppressor genes, leading to the appearance of multiple malignant characteristics. Malignant melanoma cells express different growth factors and cytokines and their receptors in respective stages of tumour progression, which by autocrine and paracrine effects enable them to grow autonomously and confer competence to metastasis. Autocrine growth factors (bFGF, MGSA/GRO, IL-8 and sometimes IL-6, PDGF-A, IL-10) produced by melanoma cells stimulate proliferation of the producing cell itself, while paracrine growth factors (for example PDGF, EGF, TGF-β, IL-1, GM-CSF, IGF-I, NGF, VEGF) modulate the microenvironment to the benefit of tumour growth and invasion. Paracrine effects include angiogenesis, stroma formation, modulation of host immune response, activation of proteolytic enzymes, adhesion or motility and metastasis formation. Some growth factors have inhibitory effects on melanocytes and early lesions (IL-1, IL-6, TGF-β, OSM, TNF and IFN) but not on advanced stage melanomas, and in some cases they switch to autocrine stimulator (IL-6, TGF-β). Understanding the involvement of different growth factors and cytokines in the molecular mechanism of melanoma progression will help to provide an insight into new future therapeutic approaches for melanoma. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)547-554
Number of pages8
JournalCytokine
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2000

Fingerprint

Melanoma
Intercellular Signaling Peptides and Proteins
Cytokines
Tumors
Interleukin-6
Interleukin-1
Neoplasm Metastasis
Neoplasms
Cytokine Receptors
Melanocytes
Cell proliferation
Nerve Growth Factor
Granulocyte-Macrophage Colony-Stimulating Factor
Tumor Suppressor Genes
Interleukin-8
Insulin-Like Growth Factor I
Oncogenes
Epidermal Growth Factor
Interleukin-10
Mental Competency

Keywords

  • Autocrine
  • Cytokines
  • Growth factor
  • Melanoma
  • Paracrine

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

Autocrine and paracrine regulation by cytokines and growth factors in melanoma. / Lázár-Molnár, Eszter; Hegyesi, H.; Tóth, S.; Falus, A.

In: Cytokine, Vol. 12, No. 6, 06.2000, p. 547-554.

Research output: Contribution to journalArticle

@article{03d7c9dc4b084cdca922e55f6d4c3700,
title = "Autocrine and paracrine regulation by cytokines and growth factors in melanoma",
abstract = "Tumour development and progression involves the expression of oncogenes and inactivation of tumour suppressor genes, leading to the appearance of multiple malignant characteristics. Malignant melanoma cells express different growth factors and cytokines and their receptors in respective stages of tumour progression, which by autocrine and paracrine effects enable them to grow autonomously and confer competence to metastasis. Autocrine growth factors (bFGF, MGSA/GRO, IL-8 and sometimes IL-6, PDGF-A, IL-10) produced by melanoma cells stimulate proliferation of the producing cell itself, while paracrine growth factors (for example PDGF, EGF, TGF-β, IL-1, GM-CSF, IGF-I, NGF, VEGF) modulate the microenvironment to the benefit of tumour growth and invasion. Paracrine effects include angiogenesis, stroma formation, modulation of host immune response, activation of proteolytic enzymes, adhesion or motility and metastasis formation. Some growth factors have inhibitory effects on melanocytes and early lesions (IL-1, IL-6, TGF-β, OSM, TNF and IFN) but not on advanced stage melanomas, and in some cases they switch to autocrine stimulator (IL-6, TGF-β). Understanding the involvement of different growth factors and cytokines in the molecular mechanism of melanoma progression will help to provide an insight into new future therapeutic approaches for melanoma. (C) 2000 Academic Press.",
keywords = "Autocrine, Cytokines, Growth factor, Melanoma, Paracrine",
author = "Eszter L{\'a}z{\'a}r-Moln{\'a}r and H. Hegyesi and S. T{\'o}th and A. Falus",
year = "2000",
month = "6",
doi = "10.1006/cyto.1999.0614",
language = "English",
volume = "12",
pages = "547--554",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - Autocrine and paracrine regulation by cytokines and growth factors in melanoma

AU - Lázár-Molnár, Eszter

AU - Hegyesi, H.

AU - Tóth, S.

AU - Falus, A.

PY - 2000/6

Y1 - 2000/6

N2 - Tumour development and progression involves the expression of oncogenes and inactivation of tumour suppressor genes, leading to the appearance of multiple malignant characteristics. Malignant melanoma cells express different growth factors and cytokines and their receptors in respective stages of tumour progression, which by autocrine and paracrine effects enable them to grow autonomously and confer competence to metastasis. Autocrine growth factors (bFGF, MGSA/GRO, IL-8 and sometimes IL-6, PDGF-A, IL-10) produced by melanoma cells stimulate proliferation of the producing cell itself, while paracrine growth factors (for example PDGF, EGF, TGF-β, IL-1, GM-CSF, IGF-I, NGF, VEGF) modulate the microenvironment to the benefit of tumour growth and invasion. Paracrine effects include angiogenesis, stroma formation, modulation of host immune response, activation of proteolytic enzymes, adhesion or motility and metastasis formation. Some growth factors have inhibitory effects on melanocytes and early lesions (IL-1, IL-6, TGF-β, OSM, TNF and IFN) but not on advanced stage melanomas, and in some cases they switch to autocrine stimulator (IL-6, TGF-β). Understanding the involvement of different growth factors and cytokines in the molecular mechanism of melanoma progression will help to provide an insight into new future therapeutic approaches for melanoma. (C) 2000 Academic Press.

AB - Tumour development and progression involves the expression of oncogenes and inactivation of tumour suppressor genes, leading to the appearance of multiple malignant characteristics. Malignant melanoma cells express different growth factors and cytokines and their receptors in respective stages of tumour progression, which by autocrine and paracrine effects enable them to grow autonomously and confer competence to metastasis. Autocrine growth factors (bFGF, MGSA/GRO, IL-8 and sometimes IL-6, PDGF-A, IL-10) produced by melanoma cells stimulate proliferation of the producing cell itself, while paracrine growth factors (for example PDGF, EGF, TGF-β, IL-1, GM-CSF, IGF-I, NGF, VEGF) modulate the microenvironment to the benefit of tumour growth and invasion. Paracrine effects include angiogenesis, stroma formation, modulation of host immune response, activation of proteolytic enzymes, adhesion or motility and metastasis formation. Some growth factors have inhibitory effects on melanocytes and early lesions (IL-1, IL-6, TGF-β, OSM, TNF and IFN) but not on advanced stage melanomas, and in some cases they switch to autocrine stimulator (IL-6, TGF-β). Understanding the involvement of different growth factors and cytokines in the molecular mechanism of melanoma progression will help to provide an insight into new future therapeutic approaches for melanoma. (C) 2000 Academic Press.

KW - Autocrine

KW - Cytokines

KW - Growth factor

KW - Melanoma

KW - Paracrine

UR - http://www.scopus.com/inward/record.url?scp=0342646934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0342646934&partnerID=8YFLogxK

U2 - 10.1006/cyto.1999.0614

DO - 10.1006/cyto.1999.0614

M3 - Article

C2 - 10843728

AN - SCOPUS:0342646934

VL - 12

SP - 547

EP - 554

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 6

ER -